Results 31 to 40 of about 2,132,550 (292)

Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling

Skeletal Muscle, 2020
Background In Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately leading to muscle loss and replacement by fibrotic tissue.
Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri, Sonia Albini   +6 more
doaj   +1 more source

Mechanism of increased risk of insulin resistance in aging skeletal muscle

Diabetology & Metabolic Syndrome, 2020
As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation ...
J. Shou, Pei-jie Chen, W. Xiao
semanticscholar   +1 more source

Regulation of Skeletal Muscle Function by Amino Acids

Nutrients, 2020
Amino acids are components of proteins that also exist free-form in the body; their functions can be divided into (1) nutritional, (2) sensory, and (3) biological regulatory roles.
Yasutomi Kamei, Yukino Hatazawa, Ran Uchitomi, Ryoji Yoshimura, S. Miura   +4 more
semanticscholar   +1 more source

Skeletal muscle: A review of molecular structure and function, in health and disease

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2019
Decades of research in skeletal muscle physiology have provided multiscale insights into the structural and functional complexity of this important anatomical tissue, designed to accomplish the task of generating contraction, force and movement. Skeletal
Kavitha Mukund, S. Subramaniam
semanticscholar   +1 more source

Bioelectrical impedance vectors analysis (BIVA) in older adults according to level of physical activity and muscle strength: a comparison of classic and specific approaches

Frontiers in Aging
IndroductionBioelectrical Impedance Analysis (BIA) is a widely used method to assess body composition. Traditional BIA models use predictive equations without considering individual characteristics such as age, sex, and activity level.
Ismael Figueiredo Rabelo, Shannon Farrell, Kieran F. Reid, Vanessa Ribeiro Dos Santos, Melissa Antunes, Vitor Cabrera Batista, Andreia Bauermann-Vieira, Luís Alberto Gobbo   +7 more
doaj   +1 more source

Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Skeletal Muscle, 2016
Background Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably TDP-43 and FUS,
Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce, Jeffrey Boone Miller   +4 more
doaj   +1 more source

Skeletal Muscle Toolbox [PDF]

Toxicologic Pathology, 2017
Evaluation of skeletal muscle frequently combines morphologic and morphometric techniques. As is the case with many organ systems, skeletal muscle has limited responses to insult or injury. Over the past several years, crucial interactions between skeletal muscle, bone, and the nervous system have been described.
openaire   +2 more sources

Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function

Nature Communications, 2020
A bioengineered skeletal muscle construct that mimics structural and functional characteristics of native skeletal muscle is a promising therapeutic option to treat extensive muscle defect injuries.
J. Kim, Ickhee Kim, Young-Joon Seol, I. Ko, J. Yoo, A. Atala, S. Lee   +6 more
semanticscholar   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells

Skeletal Muscle, 2019
Background Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in their expression patterns and effects ...
Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel   +2 more
doaj   +1 more source