Results 61 to 70 of about 897,142 (304)

IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men

Skeletal Muscle, 2011
Background While the myosin heavy chain IIb isoform (MyHC-IIb) is the predominant motor protein in most skeletal muscles of rats and mice, the messenger RNA (mRNA) for this isoform is only expressed in a very small subset of specialized muscles in adult ...
Harrison Brooke C, Allen David L, Leinwand Leslie A   +2 more
doaj   +1 more source

Correction to: Expressing a Z-disk nebulin fragment innebulin-deficient mouse muscle: effects on muscle structure and function

Skeletal Muscle, 2020
Following the publication of this paper [1], it was brought to the authors’ attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight.
Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith, Jeffrey S. Chamberlain, Henk Granzier   +7 more
doaj   +1 more source

The likely effects of thermal climate change on vertebrate skeletal muscle mechanics with possible consequences for animal movement and behaviour [PDF]

, 2019
Climate change can involve alteration in the local temperature that an animal is exposed to, which in turn may affect skeletal muscle temperature.
Abrahams, Allan, Allen, Altringham, Altringham, Angilletta, Angilletta, Barany, Beever, Bennett, Bennett, Bennett, Berchtold, Bernal, Bershitsky, Brenner, Caiozzo, Chown, Colombini, Cotton, Coughlin, Coupland, Crowley, De Ruiter, Debold, Decostre, Donley, Donley, Edwards, Evans, Ferguson, Fitts, Gabriel, Glanville, Herrel, Herrel, Hertz, Higham, Hill, Hochachka, Hou, Hudson, Huey, Husak, IPCC, James, James, James, James, John-Alder, Johnson, Johnson, Johnston, Johnston, Jones, Josephson, Lailvaux, Le Roy, Mantle, Marsh, Mautz, Michelangeli, Miles, Niehaus, Nocella, Olberding, Perry, Pinder, Place, Rall, Ranatunga, Ranatunga, Ranatunga, Rand, Reilly, Rome, Roots, Rummel, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Segal, Segre, Shuman, Somero, Stein, Storey, Swoap, Syme, Symonds, Vanhooydonck, Watkins, West, Wilson, Wilson, Wilson, Wilson, Wilson   +100 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice

Skeletal Muscle, 2017
Background Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood.
Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson   +6 more
doaj   +1 more source

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]

, 2012
The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

Skeletal Muscle, 2019
Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years.
Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller   +26 more
doaj   +1 more source

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]

, 2014
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y, Chooljian, Marc S, Conboy, Irina M, Cousin, Wendy, Elabd, Christian, Jiang, Kevin P, Kung, Sunny, Li, Ju, Upadhyayula, Pavan   +8 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source