Results 81 to 90 of about 2,150,041 (199)

The epigenetic basis of vascular calcification: focus on histone modifications

European Journal of Medical Research
Histone modifications, including methylation, acetylation, and phosphorylation, are increasingly recognized as key contributors to the development of vascular calcification.
Junmin Huang, Changheng Li, Yunan Wang, Zekun Zhong, Tongtong Ma, Lu Chen, Hongying Luo, Ziqian Bi, Tianyang Wang, Huafeng Liu, Junfeng Hao, Peng Wang, Yongzhi Xu   +12 more
doaj   +1 more source

Effects of Rosa damascena and its compounds on smooth muscle contractility

Rosa damascena, a member of the Rosaceae family, is an ancient holy plant. This ornamental plant is famous for its beneficial effects. R. damascena has been used as a traditional medicinal plant since ancient times because of its therapeutic activity ...
Sinag, Ipek Nazli, Demirel, Sadettin
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MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
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Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells.

PLoS ONE, 2017
Although dipeptidyl peptidase-4 inhibitors, a class of antidiabetic drugs, have various pleiotropic effects, it remains undetermined whether gemigliptin has a beneficial effect on vascular calcification.
Soon-Youn Choi, Hye-Myung Ryu, Eun-Joo Oh, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park   +7 more
doaj   +1 more source

Specialized mouse embryonic stem cells for studying vascular development

Stem Cells and Cloning: Advances and Applications, 2014
Drew E Glaser,1 Andrew B Burns,2 Rachel Hatano,2 Magdalena Medrzycki,3 Yuhong Fan,3 Kara E McCloskey1 1School of Engineering, University of California, Merced, CA, USA; 2School of Natural Sciences, University of California, Merced, CA, USA; 3School of ...
Glaser DE, Burns AB, Hatano R, Medrzycki M, Fan Y, McCloskey KE   +5 more
doaj  

Somatic PDGFRB activating variants promote smooth muscle cell phenotype modulation in intracranial fusiform aneurysm

Journal of Biomedical Science
Background The fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants have been identified in fusiform intracranial aneurysms, the molecular and cellular mechanisms driving ...
Li Hao, Xiaolong Ya, Jiaye Wu, Chuming Tao, Ruochen Ma, Zhiyao Zheng, Siqi Mou, Yiming Ling, Yingxi Yang, Jiguang Wang, Yan Zhang, Qing Lin, Jizong Zhao   +12 more
doaj   +1 more source

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
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NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension

JCI Insight
NKX2-5 is a member of the homeobox-containing transcription factors critical in regulating tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth muscle cell phenotypic modulation in vitro and in vascular remodeling ...
Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S. Baliga, Sarah L. Trinder, Emma Cook, Xu Shiwen, Adrian J. Hobbs, Christopher P. Denton, David J. Abraham, Markella Ponticos   +10 more
doaj   +1 more source

Characterisation of the anti-inflammatory and anti-proliferative effects of natriuretic peptides in rodents. [PDF]

, 2007
Natriuretic peptides are a family of vasoactive hormones that play important roles in cardiovascular homeostasis. These peptides exert biological effects primarily via activation of guanylate cyclase (GC)-coupled natriuretic peptide receptors (NPR) that ...
Panayiotou, C.M.
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NCOR1 deficiency in mouse smooth muscle attenuates hypertension and vascular remodeling

Communications Biology
Smooth muscle nuclear receptor corepressor 1 (NCOR1) is implicated in phenotype modulation and aortic aneurysms, but its role in blood pressure regulation remains unclear.
Lin-Juan Du, Xiao-Qian Meng, Shuo Xu, Yan Liu, Lu-Jun Zhou, Wu-Chang Zhang, Sheng-Zhong Duan   +6 more
doaj   +1 more source