Results 21 to 30 of about 788,671 (263)

Immunohistochemical characterization of the 'intimal proliferation' phenomenon in Sneddon's syndrome and essential thrombocythaemia [PDF]

, 1994
Cellular changes were immunocytochemically characterized in skin vessels of five patients with idiopathic generalized racemose livedo (Sneddon's syndrome), and one patient with localized racemose livedo associated with essential thrombocythaemia ...
Jungkunz, W., Marsch, W. C., Tamm, Ernst R., Wolter, M.   +3 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells [PDF]

, 2016
Inflammation in de-endothelialised arteries contributes to the development of cardiovascular diseases. The process that initiates this inflammatory response is the adhesion of monocytes/macrophages to exposed vascular smooth muscle cells, typically ...
McKean, Jenny S., Nixon, Graeme F., Wilson, Heather M., Wirrig, Christiane   +3 more
core   +6 more sources

PARTICIPATION OF DENDRITIC CELLS IN VASCULAR LESIONS OF CHRONIC REJECTION OF HUMAN ALLOGRAFTS [PDF]

, 1988
Immunohistochemical techniques were used to investigate the pathogenesis of obliterative arteriopathy, a major obstacle to long-term solid organ allograft survival.
Billingham, Bussolati, DeLuca, Demetris, Hansson, Hsu, Inaba, Inaba, Inaba, Jeannet, Jonasson, Kahn, Kapsenberg, Knight, Knight, Ledbetter, Mohanakumar, Munro, Palmberg, Porter, Porter, Porter, Poulter, Schwartz, Sibley, Smith, Steinman, Steinman, Steinman, Storch, Taylor, Voorhis, Wood   +32 more
core   +1 more source

Calcium Signaling in Smooth Muscle [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Changes in intracellular Ca(2+) are central to the function of smooth muscle, which lines the walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide increases to temporally varying, localized changes. The nature of the Ca(2+) signal is a reflection of the source of Ca(2+) (extracellular or intracellular) and the ...
Nelson, Mark, Hill-Eubanks, David C., Werner, Matthias E., Heppner, Thomas J., Nelson, Mark T.   +4 more
openaire   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. [PDF]

, 2019
There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking.
Aceves, Seema S, Adejumobi, Dolapo, Akuthota, Praveen, Dohil, Ranjan, Duong, Loan D, Jones, Stacie M, Kurten, Richard C, Levy, Rebecca, Newbury, Robert O, Rawson, Renee, Rothenberg, Marc E, Shoda, Tetsuo, Wright, Benjamin L   +12 more
core   +3 more sources

Vanadate and smooth muscles.

Japanese Journal of Smooth Muscle Research, 1988
Vanadate is a trace element in biological tissues which has inhibitory actions on various enzymes. It inhibits Na, K-ATPase of smooth muscle membrane. Ca-ATPase and Ca-uptake of membranous systems of smooth muscle cells are also inhibited by vanadate. Vanadate induces contractions in various smooth muscles.
openaire   +4 more sources