Results 91 to 100 of about 1,720,501 (287)

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

Effects of Arm Swing in Lower Limb Muscle Activation and Coordination During Treadmill Walking

Applied Sciences
Arm swing is an inherent aspect of human locomotion that enhances lower limb (LL) muscle activation, which may explain its benefits for stroke rehabilitation over fixed-arm approaches.
Teresa Rodríguez-Millán, Clara B. Sanz-Morère, Agnese Cherubini, Rocío Urrutia, Filipe Oliveira Barroso, José L. Pons, Jesús Tornero   +6 more
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task

Frontiers in Neural Circuits
IntroductionMotor tasks require the flexible selection and coordination of multiple muscles, which may be achieved through the organization and combination of muscle synergies.
Daniele Borzelli, Daniele Borzelli, Alberto Cacciola, Alberto Cacciola, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Angelo Alito, Demetrio Milardi, Andrea d’Avella, Andrea d’Avella   +10 more
doaj   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Muscle Network of Parkinson’s Gait: A 12-Month Longitudinal Analysis Before and After Deep Brain Stimulation Surgery

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Bilateral Deep Brain Stimulation (DBS) of the subthalamic nucleus is commonly used for treating motor symptoms in patients with advanced Parkinson’s Disease (PD). The aim of this study is to quantitatively and non-invasively evaluate motor control
Marco Ghislieri, Lorenzo Locoratolo, Fabrizio Sciscenti, Michele Lanotte, Laura Rizzi, Valentina Agostini   +5 more
doaj   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE). Methods We analyzed cross‐sectional data from 451 adults in the Approaches to Positive, Patient‐centered Experiences of ...
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 activation with the hypothesis that a ...
Hamilton, D. Lee, Gallagher, Iain J, Philp, A., Baar, Keith, Towler, Mhairi C., Bodine, S. C., Gallagher, Iain J., Philp, Andrew, Towler, M. C., Baar, K., Towler, Mhairi C, Mackenzie, M. G., Gallagher, I. J., Patton, Amy, Hamilton, David Lee, Patton, A., MacKenzie, Matthew G., Lee Hamilton, D., Bodine, Sue C, Bodine, Sue C., MacKenzie, Matthew G   +20 more
core   +1 more source

Muscle activation and coordinated movements of infant rolling

Journal of Biomechanics
Rolling is a critical step of infant development, encouraging muscle coordination and enabling independent exploration. Understanding muscle activity during infant rolling movements on a flat surface is necessary to more fully characterize how the rolling milestone is achieved.
Siegel, Danielle N., Siddicky, Safeer F., Davis, Wyatt D., Mannen, Erin M.   +3 more
openaire   +2 more sources

New AI‐Assisted Approach for Expanding the Solution Space: Application to Lattice Structure Design

Advanced Engineering Materials, EarlyView.
This work introduces an innovative framework for designing structured materials by ex panding the design space through reparameterization of qualitative variables into continuous structural descriptors. Combined with machine‐learning‐based prediction and multi‐objective optimization, the approach enables the discovery of novel lattice architectures ...
G. H. Gahimbare, Y. Beideler, D. Chune, R. De Guio, T. Roland, H. Chibane   +5 more
wiley   +1 more source