Results 81 to 90 of about 296,117 (304)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Degeneration of muscle spindles in a murine model of Pompe disease

Scientific Reports, 2023
Pompe disease is a debilitating medical condition caused by a functional deficiency of lysosomal acid alpha-glucosidase (GAA). In addition to muscle weakness, people living with Pompe disease experience motor coordination deficits including an instable ...
Bridgette Watkins, Jürgen Schultheiß, Andi Rafuna, Stefan Hintze, Peter Meinke, Benedikt Schoser, Stephan Kröger   +6 more
doaj   +1 more source

Association Between Joint Hypermobility Syndrome and Developmental Coordination Disorder – A Review. [PDF]

, 2012
Introduction: The term joint hypermobility syndrome (JHS) was adopted after clinicians became aware of the myriad of symptoms associated with this multisystemic condition.
Clark, Carol J., Khattab, Ahmed D.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Muscle Synergy During Cutting Movements in Athletes with a History of Groin Pain

Sports
This study examined muscle coordination during cutting movements in athletes with a history of groin pain. A total of 15 athletes who had experienced groin pain in the past two years (GP) and 14 healthy controls (CON) participated. Electromyography (EMG)
Hiromi Saito, Nadaka Hakariya, Teerapat Laddawong, Toshiaki Soga, Tatsuya Moteki, Koji Kaneoka, Naoto Matsunaga, Norikazu Hirose   +7 more
doaj   +1 more source

Selectivity in regeneration of the oculomotor nerve in the cichlid fish, Astronotus ocellatus [PDF]

, 1965
It has long been considered a general rule for nerve regeneration that the reinnervation of skeletal muscle is nonselective. Regenerating nerve fibers are supposed to reconnect with one skeletal muscle as readily as another according to studies covering ...
Arora, H. L., Sperry, R. W.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Multifocal tDCS targeting lower-limb cortical areas preserves late-stage endurance and tunes phase-specific coordination during incremental cycling

Frontiers in Physiology
BackgroundMultifocal transcranial direct current stimulation (m-tDCS) may modulate distributed motor networks in a polarity-dependent and task-state-dependent manner to support performance near exhaustion.
Zhiqiang Liang, Zhiqiang Liang, Zhiqiang Liang, Perianen Ramasawmy, Xue Guo, Yufei Fang, Yufei Fang, Andrea Antal, Yu Liu   +8 more
doaj   +1 more source

A Brief Analysis Of The Rehabilitation Systems Of Children With Spastic Forms Of Motor Disorders [PDF]

, 2018
The article briefly analyzes the main studies in the field of overcoming spasticity within the confines of medical and partly pedagogical approaches. It was singled out the range of the main aspects that can be used as a basis for the correction of motor
Moga, N. (Nikolay)
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source