Results 101 to 110 of about 296,117 (304)

Does Exerting Grasps Involve a Finite Set of Muscle Patterns? A Study of Intra- and Intersubject Variability of Forearm sEMG Signals in Seven Grasp Types

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Surface Electromyography (sEMG) signals are widely used as input to control robotic devices, prosthetic limbs, exoskeletons, among other devices, and provide information about someone’s intention to perform a particular movement.
Nestor J. Jarque-Bou, Margarita Vergara, Joaquin L. Sancho-Bru   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Effects of Arm Swing in Lower Limb Muscle Activation and Coordination During Treadmill Walking

Applied Sciences
Arm swing is an inherent aspect of human locomotion that enhances lower limb (LL) muscle activation, which may explain its benefits for stroke rehabilitation over fixed-arm approaches.
Teresa Rodríguez-Millán, Clara B. Sanz-Morère, Agnese Cherubini, Rocío Urrutia, Filipe Oliveira Barroso, José L. Pons, Jesús Tornero   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task

Frontiers in Neural Circuits
IntroductionMotor tasks require the flexible selection and coordination of multiple muscles, which may be achieved through the organization and combination of muscle synergies.
Daniele Borzelli, Daniele Borzelli, Alberto Cacciola, Alberto Cacciola, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Angelo Alito, Demetrio Milardi, Andrea d’Avella, Andrea d’Avella   +10 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Retraining Gastrocnemius Muscle Coordination Reduces Late-Stance Knee Contact Force in Individuals With Knee Osteoarthritis

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Musculoskeletal simulations and experiments in young adults without knee pain have demonstrated that reducing gastrocnemius muscle activity can reduce knee contact force, which may reduce pain and progression of knee osteoarthritis.
Michelle R. Joyce, Julie Muccini, Benjamin Randoing, Scott L. Delp, Scott D. Uhlrich   +4 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Muscle Network of Parkinson’s Gait: A 12-Month Longitudinal Analysis Before and After Deep Brain Stimulation Surgery

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Bilateral Deep Brain Stimulation (DBS) of the subthalamic nucleus is commonly used for treating motor symptoms in patients with advanced Parkinson’s Disease (PD). The aim of this study is to quantitatively and non-invasively evaluate motor control
Marco Ghislieri, Lorenzo Locoratolo, Fabrizio Sciscenti, Michele Lanotte, Laura Rizzi, Valentina Agostini   +5 more
doaj   +1 more source