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Exercise, Muscle Damage and Fatigue*

Sports Medicine, 1992
Fatigue as a functional sign and muscle damage as a structural sign can be observed after prolonged exercise like marathon running or after strenuous exercise, especially with the involvement of eccentric contractions. For fatigue due to prolonged exercise, hypoxic conditions and the formation of free oxygen radicals seem to be of aetiological ...
H J, Appell, J M, Soares, J A, Duarte
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Free radicals and muscle damage

British Medical Bulletin, 1993
Muscle tissue is unique in its requirement and ability to undertake very rapid and co-ordinated changes in energy supply and oxygen flux during contraction. Several studies have suggested that this renders the tissue particularly prone to oxygen radical-mediated damage.
M J, Jackson, S, O'Farrell
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Muscle damage is not a function of muscle force but active muscle strain

Journal of Applied Physiology, 1993
Contractile properties of rabbit tibialis anterior muscles were measured after eccentric contraction to investigate the mechanism of muscle injury. In the first experiment, two groups of muscles were strained 25% of the muscle fiber length at identical rates.
R L, Lieber, J, Fridén
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Muscle Damage: Nutritional Considerations

International Journal of Sport Nutrition, 1991
Most exercise results in some skeletal muscle damage. However, unaccustomed exercise andlor eccentric exercise can cause extensive damage. This exercise-induced muscle damage causes a response that can be characterized by a cascade of metabolic events. Within 24 to 48 hours, delayed onset muscle soreness and weakness, the most obvious manifestations of
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Curcumin Reduces Muscle Damage and Soreness Following Muscle‐Damaging Exercise

The FASEB Journal, 2017
The training of novice and competitive athletes involves the incorporation of unaccustomed exercise, likely to result in skeletal muscle tissue damage. The initial response, known to result in muscle soreness and swelling, and decreased forced production, is followed by a secondary inflammatory response integral in the skeletal ...
Ralf Jäger   +6 more
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Exercise-Induced Muscle Damage

International Journal of Sports Medicine, 1994
Muscular overuse is associated with structural damage of the contractile elements and reflected in delayed onset muscle soreness (DOMS). Mechanical stress is supposed to be the major contributing factor for inducing muscle damage. The initial damage is followed by an inflammatory response and eventually by regeneration.
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Muscle Damage and Endurance Events

Sports Medicine, 1986
Intensive training for and competition in endurance events like the marathon are accompanied by injury to fibres in the active skeletal muscles. Evidence for the injury comes from the increases in intramuscular enzymes and myoglobin found in the blood following the exercise, from the subjective sensation of soreness in the muscles in the post-exercise ...
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Skeletal Muscle Damage and Inflammation

Skeletal muscle is an extremely plastic tissue that can respond to a variety of insults. If the insult is sufficient, it may reduce damage to the skeletal muscle. Damage to skeletal muscle is associated with an inflammatory response. This inflammatory response is required for optimal regeneration.
Tyrone A, Washington, Eleanor R, Schrems
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Muscle damage: Scientific fundamentals

Journal of Applied Physiology, 2017
to the editor: I read the recent article by Peake et al. ([4][1]) entitled “Muscle damage and inflammation during recovery from exercise” with great interest. I would suggest adding more information about muscle damage, because in my opinion the authors talked about muscle damage minimally ...
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Molecular mechanisms of muscle damage

1993
Prior to the recognition that the protein dystrophin is missing in Duchenne dystrophy muscle and of abnormal size or reduced quantity in muscle from Becker dystrophy patients (Hoffman et al., 1987a), the assumption was made that recognition of the defective gene product(s) would lead to a rapid understanding of the manner in which this defect caused ...
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