Results 151 to 160 of about 167,552 (311)

Implementation of skeletal muscle model with advanced activation control

Applied and Computational Mechanics, 2009
The paper summarizes main principles of an advanced skeletal muscle model. The proposed mathematical model is suitable for a 3D muscle representation.
Kocková H., Cimrman R.
doaj  

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source

In vivo mouse model of calcific myonecrosis induced by injury. [PDF]

PLoS One
Kuratani M, Tsukamoto S, Hamai R, Tsuchiya K, Suzuki O, Yamada T, Katagiri T.   +6 more
europepmc   +1 more source

Exercise performance in acute and chronic cold exposure [PDF]

, 2015
Oksa, Juha, Tipton, Michael J, Wakabayashi, Hitoshi   +2 more
core   +2 more sources

Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers

Advanced Science, EarlyView.
Injured or cut peripheral nerves can be surgically rerouted to reinnervate new muscle targets. This study demonstrates reinnervated muscles exhibit enhanced separability between individual motor unit signals, which can simplify signal recording and decomposition. These findings highlight the potential of reinnervated muscle to serve as a key biological
Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor   +11 more
wiley   +1 more source