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Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load [PDF]
Scientific Reports, 2021 Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key component of PI3K ...
Naoki Kuramoto +6 more
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International Journal of Strength and Conditioning, 2021 Hypertrophy can be operationally defined as an increase in the axial cross-sectional area of a muscle fiber or whole muscle, and is due to increases in the size of pre-existing muscle fibers. Hypertrophy is a desired outcome in many sports.
Brad Schoenfeld +7 more
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F1000Research, 2020 Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is ...
Sophie Joanisse +5 more
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Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway [PDF]
Nutrition and Metabolism, 2020 Background Androgen receptor (AR) has been reported to play vital roles in exercise-induced increase of muscle mass in rats, but needs to be further verified and the mechanism behind remains unclear.
Lijun Yin +3 more
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Effect of spermidine intake on overload‐induced skeletal muscle hypertrophy in male mice [PDF]
Physiological ReportsSkeletal muscles exhibit high plasticity, such as overload‐induced hypertrophy or immobilization‐induced atrophy. During sports, skeletal muscle hypertrophy is induced by training to improve performance.
Tomohiro Iwata +4 more
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miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice [PDF]
Physiological ReportsMicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in regulating gene expression post‐transcriptionally. They are involved in various developmental and physiological processes, and their dysregulation is linked to various diseases ...
Shengyi Fei +6 more
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Frontiers in Physiology, 2019 Skeletal muscle is highly adaptable and has consistently been shown to morphologically respond to exercise training. Skeletal muscle growth during periods of resistance training has traditionally been referred to as skeletal muscle hypertrophy, and this ...
Cody T. Haun +5 more
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Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy
eLife, 2017 Fusion of skeletal muscle stem/progenitor cells is required for proper development and regeneration, however the significance of this process during adult muscle hypertrophy has not been explored.
Qingnian Goh, Douglas P Millay
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Benign masseter muscle hypertrophy
Brazilian Journal of Otorhinolaryngology, 2008 Summary: Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders ...
Daniel Zeni Rispoli +5 more
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Revisiting the roles of protein synthesis during skeletal muscle hypertrophy induced by exercise [PDF]
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2019 Protein synthesis is deemed the underpinning mechanism enhancing protein balance required for skeletal muscle hypertrophy in response to resistance exercise.
Vandré C. Figueiredo
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