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Hypertrophy can be operationally defined as an increase in the axial cross-sectional area of a muscle fiber or whole muscle, and is due to increases in the size of pre-existing muscle fibers. Hypertrophy is a desired outcome in many sports.
Brad Schoenfeld+7 more
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Effect of spermidine intake on overload‐induced skeletal muscle hypertrophy in male mice [PDF]
Skeletal muscles exhibit high plasticity, such as overload‐induced hypertrophy or immobilization‐induced atrophy. During sports, skeletal muscle hypertrophy is induced by training to improve performance.
Tomohiro Iwata+4 more
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Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is ...
Sophie Joanisse+5 more
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miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice [PDF]
MicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in regulating gene expression post‐transcriptionally. They are involved in various developmental and physiological processes, and their dysregulation is linked to various diseases ...
Shengyi Fei+6 more
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Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence general metabolism, locomotion, eating and respiration.
Roberta Sartori+2 more
exaly +2 more sources
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have been extensively researched since the landmark report by Morpurgo (1897) of "work-induced hypertrophy" in dogs that were treadmill-trained. Much of the pre-clinical rodent
Roberts MD+13 more
europepmc +2 more sources
Molecular Mechanisms of Skeletal Muscle Hypertrophy
Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and by mechanical signals mediating the effect of resistance exercise. Muscle growth during hypertrophy is controlled at the translational level, through the stimulation of ...
Schiaffino S.+3 more
openaire +6 more sources
Triceps surae muscle hypertrophy is greater after standing versus seated calf-raise training [PDF]
Background: The triceps surae muscle plays important roles in fundamental human movements. However, this muscle is relatively unresponsive to resistance training (difficult to hypertrophy) but prone to atrophy with inactivity compared with other muscles.
Momoka Kinoshita+12 more
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Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy
Fusion of skeletal muscle stem/progenitor cells is required for proper development and regeneration, however the significance of this process during adult muscle hypertrophy has not been explored.
Qingnian Goh, Douglas P Millay
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Skeletal muscle is highly adaptable and has consistently been shown to morphologically respond to exercise training. Skeletal muscle growth during periods of resistance training has traditionally been referred to as skeletal muscle hypertrophy, and this ...
Cody T. Haun+5 more
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