Results 41 to 50 of about 1,126,451 (240)

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

open access: yesAdvanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang   +4 more
wiley   +1 more source

Primary muscle hypertrophy of the colon in a cat: a rare presentation

open access: yesBrazilian Journal of Veterinary Pathology, 2015
In animals and humans, intestinal muscular hypertrophy has only been observed in the small intestine, and this appears to be the first report of the disease affecting the large intestine.
Juneo F. Silva   +3 more
doaj   +1 more source

Biohybrid Crawling Robot With Spiral‐Spring Backbone and Inclined Legs for Enhanced Locomotion

open access: yesAdvanced Materials, EarlyView.
We present a biohybrid crawling robot integrating a muscle ring with a flexible skeleton combining two complementary structural elements. The spiral‐spring backbone enables large‐amplitude bending without compromising axial stability, while outward‐inclined legs with unequal front–rear lengths effectively convert deformation into directional strides ...
Tomohiro Morita   +2 more
wiley   +1 more source

Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]

open access: yes, 1997
The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Arber, S.   +8 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem   +24 more
wiley   +1 more source

PENGARUH LATIHAN SQUAT DAN LEG PRESS TERHADAP STRENGTH DAN HYPERTROPHY OTOT TUNGKAI

open access: yesMultilateral: Jurnal Pendidikan Jasmani dan Olahraga, 2016
Strength is one of the basic components biomotor that is needed in every sport field. In order to achieve optimal performance achievement, then the power should be increased  as  the  underlying  basis  of  the  formation  of  other  biomotor  components.
Aryadi Rachman
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

miRNA transcriptome and myofiber characteristics of lamb skeletal muscle during hypertrophic growth1

open access: yesFrontiers in Genetics, 2022
Postnatal muscle growth is achieved through hypertrophy of the muscle fibers and is impacted by the activity of satellite cells, the quiescent muscle stem cell.
M. A. Greene   +5 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

A Critical Evaluation of the Biological Construct Skeletal Muscle Hypertrophy: Size Matters but So Does the Measurement

open access: yesFrontiers in Physiology, 2019
Skeletal muscle is highly adaptable and has consistently been shown to morphologically respond to exercise training. Skeletal muscle growth during periods of resistance training has traditionally been referred to as skeletal muscle hypertrophy, and this ...
Cody T. Haun   +5 more
doaj   +1 more source

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