Results 121 to 130 of about 255,284 (355)
Advanced Science, EarlyView.This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta +14 more
wiley +1 more source
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Advanced Science, EarlyView.Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley +1 more source
Advanced Science, EarlyView.This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma +10 more
wiley +1 more source
Paradoxical bulging of muscle after injection of botulinum neurotoxin type A into hypertrophied masseter muscle [PDF]
, 2012 Sang Ju Lee +4 more
openalex +1 more source
Advanced Science, EarlyView.The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang +10 more
wiley +1 more source
CL316,243, a β3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength [PDF]
, 2016 Daniela Puzzo +11 more
openalex +1 more source
Research Progress on Idebenone in Neurodegenerative Diseases
AGING MEDICINE, EarlyView.The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Yanqing Zhang +10 more
wiley +1 more source
Normalization of Gene Expression Data Revisited: The Three Viewpoints of the Transcriptome in Human Skeletal Muscle Undergoing Load-induced Hypertrophy and Why They Matter [PDF]
, 2021 Yusuf Khan +3 more
openalex +1 more source
Chronic intestinal pseudo-obstruction in a Bernese Mountain Dog [PDF]
, 2009 Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare syndrome characterized by chronic intestinal dilation and dysmotility in the absence of mechanical obstruction.
Chiers, Koen +5 more
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