Results 31 to 40 of about 779,091 (316)

MuRF1/TRIM63, Master Regulator of Muscle Mass [PDF]

International Journal of Molecular Sciences, 2020
The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play important roles during skeletal muscle atrophy. Since then, numerous studies have been conducted to decipher the roles, molecular mechanisms and regulation of this enzyme.
Peris-Moreno, Dulce, Taillandier, Daniel, Polge, Cécile   +2 more
openaire   +5 more sources

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle

Skeletal Muscle
Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity of muscle stem cells, or satellite cells ...
Nathan Serrano, Pieter Jan Koopmans, Kevin A. Murach   +2 more
doaj   +1 more source

Comparison of Physical Function among Elderly Japanese Women with and without Low Bone Mass and Low Muscle Mass: A Cross-Sectional Study of Older Women Who Engage in Regular Physical Activity

Geriatrics, 2022
A decline in physical function is common among elderly people who have lost both bone and muscle mass. The aim of this study was to investigate the relationship between low bone and muscle mass and physical function in elderly women of different age ...
Tsuyoshi Katsurasako, Shin Murata, Akio Goda, Hideki Nakano, Kayoko Shiraiwa, Jun Horie, Koji Nonaka   +6 more
doaj   +1 more source

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Body composition associations with muscle strength in older adults living in Auckland, New Zealand.

PLoS ONE, 2021
BackgroundAging is associated with decreases in muscle strength and simultaneous changes in body composition, including decreases in muscle mass, muscle quality and increases in adiposity.MethodsAdults (n = 369; 236 females) aged 65-74 years living ...
Anne N Hiol, Pamela R von Hurst, Cathryn A Conlon, Owen Mugridge, Kathryn L Beck   +4 more
doaj   +1 more source

Signaling pathways controlling skeletal muscle mass [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2013
The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of
Egerman, Marc A., Glass, David J.
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females

BMC Cancer
Background Skeletal muscle atrophy during cancer-induced cachexia remains a significant challenge in cancer management. Mitochondrial defects precede muscle mass and functional losses in models of cancer cachexia (CC).
Francielly Morena, Seongkyun Lim, Ana Regina Cabrera, Toby L. Chambers, Pieter J. Koopmans, Stavroula Tsitkanou, Sabin Khadgi, Calvin Peterson, Eleanor R. Schrems, Ruqaiza Muhyudin, Sepideh Shakeri, Kevin Zhao, Devan Mishra, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +15 more
doaj   +1 more source

Differential metabolites in cirrhotic patients with hepatitis B and muscle mass loss

Frontiers in Nutrition, 2023
BackgroundSarcopenia leads to complications (infections, hepatic encephalopathy and ascites) and poor overall survival in patients with cirrhosis, in which the phenotypic presentation is loss of muscle mass.
Xuechun Liu, Lei Han, Shenghua Bi, Xueli Ding, Qi Sheng, Yueping Jiang, Ge Guan, Qinghui Niu, Xue Jing   +8 more
doaj   +1 more source