Results 41 to 50 of about 4,740,244 (195)

Frequency and functional translation of low muscle mass in overweight and obese patients with COPD

Respiratory Research, 2021
Background Cut offs for fat-free mass index (FFMI) and appendicular skeletal muscle mass index (ASMI) are available for diagnosing low muscle mass in patients with COPD. This study aimed to investigate: (1) the frequency of low muscle mass (FFMI and ASMI)
Felipe V. C. Machado, Martijn A. Spruit, Miriam T. J. Groenen, Sarah Houben-Wilke, Paula P. van Melick, Nidia A. Hernandes, Annemie M. W. J. Schols, Fabio Pitta, Emiel F. M. Wouters, Frits M. E. Franssen   +9 more
doaj   +1 more source

Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity

BMC Genomics
Background Sarcopenic obesity (SO) is the combined condition of sarcopenia and obesity, which commonly occurs in the older adult population. SO is associated with poor physical function, increased risk of musculoskeletal injury, and reduced quality of ...
Eleanor R. Schrems, Ana Regina Cabrera, Ronald G. Jones, Francielly Morena, Kevin A. Murach, Nicholas P. Greene, Tyrone A. Washington   +6 more
doaj   +1 more source

Low muscle mass, low muscle function, and sarcopenia in the urban and rural elderly

Scientific Reports, 2022
Health outcomes of the elderly vary between rural and urban areas. Sarcopenia is diagnosed as loss of muscle strength or impaired physical performance, namely “low muscle function” and low muscle mass.
Sung Woo Moon, Kwang-Joon Kim, Han Sung Lee, Young Mi Yun, Jong-Eun Kim, You Jin Chun, Chang Oh Kim   +6 more
doaj   +1 more source

Comparison of Physical Function among Elderly Japanese Women with and without Low Bone Mass and Low Muscle Mass: A Cross-Sectional Study of Older Women Who Engage in Regular Physical Activity

Geriatrics, 2022
A decline in physical function is common among elderly people who have lost both bone and muscle mass. The aim of this study was to investigate the relationship between low bone and muscle mass and physical function in elderly women of different age ...
Tsuyoshi Katsurasako, Shin Murata, Akio Goda, Hideki Nakano, Kayoko Shiraiwa, Jun Horie, Koji Nonaka   +6 more
doaj   +1 more source

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 activation with the hypothesis that a ...
Hamilton, D. Lee, Gallagher, Iain J, Philp, A., Baar, Keith, Towler, Mhairi C., Bodine, S. C., Gallagher, Iain J., Philp, Andrew, Towler, M. C., Baar, K., Towler, Mhairi C, Mackenzie, M. G., Gallagher, I. J., Patton, Amy, Hamilton, David Lee, Patton, A., MacKenzie, Matthew G., Lee Hamilton, D., Bodine, Sue C, Bodine, Sue C., MacKenzie, Matthew G   +20 more
core   +1 more source

Association between body composition and bone mineral density in community-dwelling older adults from Chile: a sex-stratified DXA-based cross-sectional study

BMC Geriatrics
Introduction Decreased bone mineral density (BMD) remains one of the main determinants of frailty and fracture risk in older adults. Lean mass is an important contributor to bone health through mechanical loading and muscle–bone interactions ...
Nicole Fritz-Silva, Cristian Mansilla-Antilef, María Angélica Castillo-Cerda, Carla Bittner-Hofmann, Carol Ule-Marín   +4 more
doaj   +1 more source

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

Assessment of muscle mass and strength in mice [PDF]

BoneKEy Reports, 2015
Muscle weakness is an important phenotype of many diseases that is linked to impaired locomotion and increased mortality. The force that a muscle can generate is determined predominantly by muscle size, fiber type and the excitation-contraction coupling process. Here we describe methods for the histological assessment of whole muscle to determine fiber
Bonetto, Andrea, Andersson, Daniel C., Waning, David L.   +2 more
openaire   +2 more sources

Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle [PDF]

, 2011
Supra-physiological levels of vitamin D induce skeletal muscle atrophy, which may be particularly detrimental in already sarcopaenic elderly. Neither the cause nor whether the atrophy is fibre type specific are known.
Jaspers, R.T., Rittweger, Jörn, Janwillem Testerink, Richard T. Jaspers, Hans Degens, Testerink, J., Degens, Hans, Jörn Rittweger, Degens, H., de Haan, A., de Haan, Arnold, Jaspers, Richard, Haan, A. de, Testerink, Janwillem, Arnold de Haan, Rittweger, J.   +15 more
core   +2 more sources

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science
A detailed analysis of how muscle fiber nuclei (myonuclei) respond to a hypertrophic stimulus could provide a critical step toward understanding compromised skeletal muscle plasticity with age.
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
doaj   +1 more source