Results 61 to 70 of about 3,187,441 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Bioactivity in Whey Proteins Influencing Energy Balance [PDF]

, 2012
Peer-reviewedObesity develops due to energy (food) intake exceeding energy expenditure. Nutrients that reduce the positive energy balance are thus being considered as therapies to combat obesity.
Nilaweera, Kanishka, Cotter, Paul D., Korpela, Riitta, McAllan, Liam, Roche, Helen M.   +4 more
core   +1 more source

Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]

, 2006
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The effect of strength training on muscle cellular stress in prostate cancer patients on ADT

Endocrine Connections, 2016
Background Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with several side effects, including loss of muscle mass. Muscle atrophy is associated with reduced mitochondrial function and increased muscle cellular stress that may
T S Nilsen, L Thorsen, C Kirkegaard, I Ugelstad, S D Fosså, T Raastad   +5 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance. [PDF]

, 2013
The purpose of this study was to assess the influence of age, training status, and muscle fiber-type distribution on cycling efficiency. Forty men were recruited into one of four groups: young and old trained cyclists, and young and old untrained ...
Wiles, J., Hopker, J., Coleman, Damian A, Jobson, Simon A., Gregson, Hannah C, Wiles, Jonathan, Coleman, D., Gregson, H., Coleman, Damian A., Hopker, James G., Passfield, L., von der Haar, Tobias, Passfield, Louis, Von der Haar, T., Jobson, S., Gregson, Hannah C.   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Structural studies on protein scaffolds related to muscle physiology and disease : the titin filament, its associated component MuRF-1 and nuclear LAP2[alpha] [PDF]

, 2006
The titin molecule has a length of overµm and functions as a colossal protein scaffold in the muscle sarcomere. Up to 90% of its total mass is composed of repetitive immunoglobulin (Ig) and fibronectin (FnIII) domains that form linear tandems ...
Mrosek, Michael Christian
core   +1 more source

Co-oxidation behavior between lipid and protein in muscle food: a review

Food Science of Animal Products
In recent decades, the oxidation of proteins and lipids in muscle meals has received increased study interest, as it is generally understood that such oxidation affects both the sensory quality and nutritional value of these goods.
Yuanbo Hu, Wei Cui, Hui Zhou, Zhaoming Wang, Baocai Xu   +4 more
doaj   +1 more source