Results 71 to 80 of about 67,474 (282)

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

The Mammalian Muscle Spindle

, 1997
A brief, summarizing description is given of the structure and physiology of the mammalian muscle spindle. The question is addressed, What might be the roles of the three different kinds of intrafusal fibers on which the sensory endings lie? The role of
U Proske
core   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Dynamic response of human muscle spindle afferents to stretch

, 1990
1. One hundred and twenty-four muscle afferents from the finger extensor muscles were recorded from the radial nerve in human subjects. 2. The afferents were provisionally classified as muscle spindle primary (78/124) and secondary afferents (25/124 ...
A. B. Vallbo, B. B. Edin
core   +2 more sources

Impaired muscle spindle function in murine models of muscular dystrophy. [PDF]

, 2020
Key points: Muscular dystrophy patients suffer from progressive degeneration of skeletal muscle fibres, sudden spontaneous falls, balance problems, as well as gait and posture abnormalities.
Kröger, S., Bittner, R.E., Reginald E. Bittner, Gerwin, L., Rossmanith, S., Schultheiß, J., Laura Gerwin, Heinrich Brinkmeier, Bittner, Reginald, Kröger, Stephan, Haupt, Corinna, Schultheiß, Jürgen, Corinna Haupt, Brinkmeier, H., Gerwin, Laura, Rossmanith, Sarah, Stephan Kröger, Brinkmeier, Heinrich, Sarah Rossmanith, Bittner, Reginald E., Haupt, C., Jürgen Schultheiß   +21 more
core   +1 more source

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source

Design and Fabrication of Fibrous Spindle‐Like Constructs Using a Melt Electrohydrodynamic Writing Process

Macromolecular Materials and Engineering
Advanced manufacturing of 3D‐structured materials enables the production of biomimetic muscle tissues. While models of muscle tissue exist, current approaches possess a limited ability to capture essential elements of the muscle tissue microarchitecture.
Ahmadreza Zaeri, Kai Cao, Fucheng Zhang, Ralf Zgeib, Robert C. Chang   +4 more
doaj   +1 more source

A role for neuregulin1 signaling in muscle spindle differentiation

, 2002
The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles.
Hippenmeyer, Simon, Shneider, Neil A., Burden, S.J., Birchmeier, C., Birchmeier, Carmen, Arber, S., Hippenmeyer, S., Burden, S. J., Shneider, N.A., Shneider, N. A., Jessell, Thomas M., Jessell, T.M., Jessell, T. M., Burden, Steven J., Arber, Silvia   +14 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report

Case Reports in Oncology, 2016
An inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by inflammatory infiltration of plasma cells, lymphocytes, and eosinophils.
Toshiki Etani, Taku Naiki, Takashi Nagai, Keitaro Iida, Ryosuke Ando, Aya Naiki-Ito, Noriyasu Kawai, Keiichi Tozawa, Kentaro Mizuno, Atsushi Okada, Tohru Mogami, Takahiro Yasui   +11 more
doaj   +1 more source