Results 81 to 90 of about 11,182 (240)

Botulinum toxin: mechanisms of action Toxina botulínica: mecanismos de ação

Arquivos de Neuro-Psiquiatria, 2005
This review describes therapeutically relevant mechanisms of action of botulinum toxin (BT). BT's molecular mode of action includes extracellular binding to glycoproteine structures on cholinergic nerve terminals and intracellular blockade of the ...
Dirk Dressler, Fereshte Adib Saberi, Egberto Reis Barbosa   +2 more
doaj   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Unveiling sleep disturbances in KCNB1‐related disorders: Insights from a cohort of 78 individuals

Epilepsia Open, EarlyView.
Abstract Objectives Sleep disturbances are frequent comorbidities in epilepsies and developmental encephalopathies. This study aimed to characterize sleep abnormalities in individuals with KCNB1‐related disorders, focusing on their prevalence, clinical manifestations, and impact on daily functioning.
Giovanna Scorrano, Delphine Breuillard, Anais Thimon, Nicole Chemaly, Rima Nabbout   +4 more
wiley   +1 more source

Dynamic Culture of TDSCs on a Mechanically Biomimetic PCL/COL Flexible Substrate

FlexTech, EarlyView.
A mechanically biomimetic PCL/COL flexible substrate with electrospun fibers promoted the alignment and tenogenic differentiation of TDSCs under dynamic stimulation. This platform links structural design to cellular response and offers a promising strategy for tendon tissue engineering.
Changyun Wang, Jun Wu, Yuwu Zhang, Yu Wei, Shunze Cao   +4 more
wiley   +1 more source

Attenuation of muscle spindle firing with artificially increased series compliance during stretch of relaxed muscle

Experimental Physiology
Muscle spindles relay vital mechanosensory information for movement and posture, but muscle spindle feedback is coupled to skeletal motion by a compliant tendon.
Emily M. Abbott, Jacob D. Stephens, Surabhi N. Simha, Leo Wood, Paul Nardelli, Timothy C. Cope, Gregory S. Sawicki, Lena H. Ting   +7 more
doaj   +1 more source

Monitoring and assessment for obstructive sleep apnea

FlexMat, EarlyView.
This review systematically classifies Obstructive Sleep Apnea (OSA) monitoring indicators into three categories: physical, biochemical, and electrophysiological indicators, and lists several methods for each category. Abstract Obstructive sleep apnea (OSA) is a common chronic sleep‐disordered breathing disease characterized by recurrent upper airway ...
Yaowen Xu, Feifei Lin, Shujiao Chen, Zhen You, Shujing Zhu, Weiwei Zhao, Qiang Zhao   +6 more
wiley   +1 more source

Expression of MyHC-15 and -2x in human muscle spindles: An immunohistochemical study. [PDF]

J Anat, 2023
Smerdu V.
europepmc   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

The contribution of muscle spindles to position sense measured with three different methods. [PDF]

Exp Brain Res, 2023
Roach C, Love C, Allen T, Proske U.
europepmc   +1 more source

Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications

Head &Neck, EarlyView.
ABSTRACT Background Beyond follicular‐derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers. Methods Retrospective case series.
David Z. Allen, S. Mohsen Hosseini, Mark Zafereo, Miriam Lango, Elizabeth Gardner Grubbs, Priyanka Iyer, Shreyaskumar R. Patel, Vinod Ravi, Naifa Lamki Busaidy, Rui Jennifer Wang, Michelle D. Williams, Maria E. Cabanillas, Anastasios Maniakas   +12 more
wiley   +1 more source