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Muscle wasting in cardiac cachexia
The International Journal of Biochemistry & Cell Biology, 2005 Cardiac cachexia is a serious complication of chronic heart failure which is characterized by complex changes that overall lead to a catabolic/anabolic imbalance resulting in body wasting and a poor prognosis. The wasting process affects all body components, but particularly the skeletal musculature, causing extreme fatigue and weakness, especially in ...
Strassburg, Sabine +2 more
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Muscle wasting in heart failure
Wiener klinische Wochenschrift, 2016 Muscle wasting and malnutrition are common complications in patients with advanced heart failure (HF); however, both remain underdiagnosed and undertreated although they both play relevant roles in the progression of HF. The risk of muscle wasting in patients with HF increases in those patients with malnutrition or at risk of malnutrition.
Masakazu, Saitoh +2 more
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Current Opinion in Clinical Nutrition and Metabolic Care, 2015
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Attaix, Didier +2 more
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Attaix, Didier +2 more
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The International Journal of Biochemistry & Cell Biology, 2013
Skeletal muscle loss appears to be the most significant clinical event in cancer cachexia and is associated with a poor outcome. With regard to such muscle loss, despite extensive study in a range of models, there is ongoing debate as to whether a reduction in protein synthesis, an increase in degradation or a combination of both is the more relevant ...
N, Johns, N A, Stephens, K C H, Fearon
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Skeletal muscle loss appears to be the most significant clinical event in cancer cachexia and is associated with a poor outcome. With regard to such muscle loss, despite extensive study in a range of models, there is ongoing debate as to whether a reduction in protein synthesis, an increase in degradation or a combination of both is the more relevant ...
N, Johns, N A, Stephens, K C H, Fearon
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Clinical Science, 1988
1. We have investigated arteriovenous exchanges of tyrosine and 3-methylhistidine across leg tissue in the postabsorptive state as specific indicators of net protein balance and myofibrillar protein breakdown, respectively, in eight patients with emphysema and in 11 healthy controls. Whole-body protein turnover was measured using l-[1-13C]leucine.
W L, Morrison +3 more
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1. We have investigated arteriovenous exchanges of tyrosine and 3-methylhistidine across leg tissue in the postabsorptive state as specific indicators of net protein balance and myofibrillar protein breakdown, respectively, in eight patients with emphysema and in 11 healthy controls. Whole-body protein turnover was measured using l-[1-13C]leucine.
W L, Morrison +3 more
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The International Journal of Biochemistry & Cell Biology, 2005
Calpains are intracellular nonlysosomal Ca(2+)-regulated cysteine proteases. They mediate regulatory cleavages of specific substrates in a large number of processes during the differentiation, life and death of the cell. The purpose of this review is to synthesize our current understanding of the participation of calpains in muscle atrophy.
Bartoli, Marc, Richard, I
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Calpains are intracellular nonlysosomal Ca(2+)-regulated cysteine proteases. They mediate regulatory cleavages of specific substrates in a large number of processes during the differentiation, life and death of the cell. The purpose of this review is to synthesize our current understanding of the participation of calpains in muscle atrophy.
Bartoli, Marc, Richard, I
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Orthopaedic Nursing, 2003
The loss of lean body mass (muscle wasting) is initiated by cascades or events that precipitate increased proteolysis. Muscle wasting is stimulated by internal and external factors. Humorally related feedback loops stimulated by disease states, e.g., cancer, inflammatory myopathies, leukemia, or sepsis, and initiated as a response to systemic ...
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The loss of lean body mass (muscle wasting) is initiated by cascades or events that precipitate increased proteolysis. Muscle wasting is stimulated by internal and external factors. Humorally related feedback loops stimulated by disease states, e.g., cancer, inflammatory myopathies, leukemia, or sepsis, and initiated as a response to systemic ...
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Current Opinion in Clinical Nutrition and Metabolic Care, 2015
The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.An alteration of energy balance ...
Josep M, Argilés +2 more
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The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.An alteration of energy balance ...
Josep M, Argilés +2 more
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Scientific American, 2018
The article discusses the use of the gene editing technique CRISPR/Cas9 to increase dystrophin as a way to treat dogs with duchenne muscular dystrophy, referencing a study coauthored by molecular biologist Eric Olson in the "Science" journal.
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The article discusses the use of the gene editing technique CRISPR/Cas9 to increase dystrophin as a way to treat dogs with duchenne muscular dystrophy, referencing a study coauthored by molecular biologist Eric Olson in the "Science" journal.
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Sex Differences in Muscle Wasting
2017With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration.
Lindsey J, Anderson +2 more
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