Results 61 to 70 of about 116,613 (300)
ERJ Open ResearchIntroduction Sarcopenia contributes significantly to decreased exercise tolerance, reduced quality of life and worse overall prognosis, independent of lung function severity in chronic respiratory disease including bronchiectasis.
Adriana Núñez-Robainas +7 more
doaj +1 more source
Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise
Journal of Cachexia, Sarcopenia and Muscle, 2023 After a severe burn injury, a systemic stress response activates metabolic and inflammatory derangements that, among other, leads to muscle mass loss (muscle wasting). These negative effects on skeletal muscle continue for several months or years and are
Dorien Dombrecht +7 more
doaj +1 more source
Neuromuscular junction degeneration in muscle wasting [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2016 Denervation is a hallmark of age-related and other types of muscle wasting. This review focuses on recent insights and current viewpoints regarding the mechanisms and clinical relevance of maintaining the neuromuscular junction to counteract muscle wasting resulting from aging or neural disease/damage.Activity-dependent regulation of autophagy, the ...
Rudolf, R, Deschenes, Mr, SANDRI, MARCO
openaire +3 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]
, 2013 Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor +75 more
core +2 more sources
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Growing Older, Staying Strong: Preventing Sarcopenia Through Strength Training [PDF]
, 2003 Older people can reduce their frailty, become more mobile and stave off the muscle-wasting condition known as sarcopenia by working out as little as twice a ...
Michael J. Hewitt
core
ACT-ONE - ACTION at last on cancer cachexia by adapting a novel action beta-blocker [PDF]
, 2016 Novel action beta-blockers combine many different pharmacological effects. The espindolol exhibits effects through β and central 5-HT1α receptors to demonstrate pro-anabolic, anti-catabolic, and appetite-stimulating actions.
Lainscak, Mitja, LAVIANO, Alessandro
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Scientific Reports, 2017 Cancer-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology. Current consensus is that multiple factors contribute to cancer-induced muscle wasting, and therefore therapy requires combinational ...
Guohua Zhang +5 more
doaj +1 more source