Results 131 to 140 of about 92,711 (302)

Learning‐Based Soft Robotic Grasping: Recent Progress and Remaining Challenges

Advanced Robotics Research, EarlyView.
This review analyzes learning‐based soft robotic grasping from a pipeline‐oriented perspective, encompassing soft gripper design, multimodal sensing, and learning‐based planning and control. It surveys key neural network architectures and benchmark datasets and identifies critical challenges such as sim‐to‐real transfer, generalization, and continual ...
Arnab Majumder, Jelizaveta Konstantinova, Graham Deacon, Kaspar Althoefer   +3 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Synaptic vulnerability in spinal muscular atrophy [PDF]

, 2010
Mounting evidence suggests that synaptic connections are early pathological targets in many neurodegenerative diseases, including motor neuron disease. A better understanding of synaptic pathology is therefore likely to be critical in order to develop
Murray, Lyndsay M.
core  

Using Electromyography and Biomedical Engineering to Assist Muscular Atrophy Patients

, 2023
Patients with Muscular Atrophy disorders such as Spinal Muscular Atrophy suffer from decreased muscular capacity making complex motor functions such as walking or eating difficult.
Harris, Johnathan
core  

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Feasibility of combined treatment for type III spinal muscular atrophy: a pilot study

, 2017
Nataliia Sych, 1 Mariya Klunnyk,1 Iryna Matiyashchuk,1 Mariya Demchuk,1 Olena Ivankova,1 Andriy Sinelnyk,1 Khrystyna Sorochynska,2 Marina Skalozub3 1Clinical Department, 2Stem Cells Bank, 3Laboratory and Biotechnology Department, Cell Therapy Center ...
Sych N, Matiyashchuk I, Sorochynska K, Klunnyk M, Sinelnyk A, Skalozub M, Ivankova O, Demchuk M   +7 more
core  

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Rehabilitation management for patients with spinal muscular atrophy: a review

Orphanet Journal of Rare Diseases
The rehabilitation management of patients with spinal muscular atrophy is a complex, multidisciplinary process aimed at slowing disease progression, preventing complications, and enhancing patients’ quality of life.
Wei Song, Xiaohua Ke
doaj   +1 more source

Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

, 2018
Yuan Wang,1,* Yali Shao,1 Yuqing Gao,1 Guoran Wan,2 Dong Wan,3,* Huifeng Zhu,1 Yan Qiu,1 Xiyue Ye1 1Department of Chinese Medicine, College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing Engineering Research
Qiu Y, Ye XY, Gao YQ, Zhu HF, Shao YL, Wan GR, Wang Y, Wan D   +7 more
core  

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source