Results 151 to 160 of about 393,528 (292)

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

A Model for Spinal Muscular Atrophy Disease Registry for Iran [PDF]

Payesh
Objective(s): Spinal muscular atrophy is a rare genetic disease of neuromuscular and it is considered the main cause of death of newborns, which affects spinal motor neurons.
Hadiseh Azadi Cheshmekabodi, Farahnaz Sadoughi, Somayeh Nasiri   +2 more
doaj  

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Implementation of spinal muscular atrophy screening for newborns at a Singapore tertiary hospital

Annals, Academy of Medicine, Singapore
Shreya S Shetty, Janaki Abirami Palaniappan, Wei Cheng David Kuek, Dan Thu Van, Jia Ming Low, Furene Wang, Benedict Yan, Stacey KH Tay, Hui-Lin Chin   +8 more
doaj   +1 more source

Nationwide Implementation of Newborn Screening for Spinal Muscular Atrophy in Canada. [PDF]

Neurol Genet
McMillan HJ, Osman H, Kernohan K, Lacaria M, Hume SL, Muranyi A, Sinclair G, Selby KA, Giguère Y, Antonishyn NA, Van Caeseele P, Evans C, Liu Z, Oskoui M.   +13 more
europepmc   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Clinical Practice of Single-Molecule Real-Time Sequencing in the Diagnosis of Spinal Muscular Atrophy. [PDF]

Mol Genet Genomic Med
Wei H, Zheng YW, Zhang NK, Gao TL, Zheng JX, Li TY, Hong SR.   +6 more
europepmc   +1 more source

A Recyclable and Biodegradable High‐Performance Piezoelectric Nanogenerator for Self‐Powered Biosensing and Assistive Human‐Machine Interaction

Advanced Science, EarlyView.
By exploiting multiscale hydrogen‐bonding interactions between HFPD and TOCNF, the composite simultaneously achieves a high piezoelectric coefficient (14.0 pC·N−1), outstanding flexibility (100 000 bending cycles), water‐assisted recyclability, excellent biodegradability, and sensitive wearable/implantable sensing for motion, speech, and Morse code ...
Tingshuai Luo, Tian Xiao, Luyu Zhang, Bailang Zhang, Shengchang Lu, He Xiao, Jianguo Li, Kai Liu, Chaoji Chen, Hui Wu   +9 more
wiley   +1 more source

Spinal muscular atrophy: Biology, pathogenesis, and therapeutic advances. [PDF]

Ther Adv Neurol Disord
René CA, Parks RJ.
europepmc   +1 more source