Results 31 to 40 of about 218,393 (308)

Interspecies Translation of Disease Networks Increases Robustness and Predictive Accuracy [PDF]

, 2011
© 2011 Anvar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Seyed Yahya Anvar, Gert-Jan B. van Ommen, Raz, V., Vered Raz, Raz, V, Ommen, G.J.B. van, Tucker, A., Tucker, A, Allan Tucker, Silvere M van der Maarel, Anvar, S.Y., van der Maarel, SM, Veronica Vinciotti, Andrea Venema, Silvere M. van der Maarel, Hoen, P.A.C. 't, Vinciotti, V., Peter A C 't Hoen, van Ommen, G-JB, Maarel, S.M. van der, Vinciotti, V, Venema, A, Anvar, SY, Venema, A., Peter A. C. ‘t Hoen, Gert-Jan B van Ommen, 't Hoen, PAC   +26 more
core   +1 more source

Redox homeostasis and inflammation in fibroblasts of patients with Friedreich Ataxia: a possible cross talk

Frontiers in Molecular Neuroscience
Redox homeostasis is impaired in Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial protein frataxin.
Andrea Quatrana, Sara Petrillo, Caterina Torda, Eleonora De Santis, Enrico Bertini, Fiorella Piemonte   +5 more
doaj   +1 more source

Pulmonary and Physical Rehabilitation in Critically Ill Patients [PDF]

Acute and Critical Care, 2019
Some patients admitted to the intensive care unit (ICU) because of an acute illness, complicated surgery, or multiple traumas develop muscle weakness affecting the limbs and respiratory muscles during acute care in the ICU.
Myung Hun Jang, Myung-Jun Shin, Yong Beom Shin   +2 more
doaj   +1 more source

Editorial for the Genetics of Muscular Dystrophies from the Pathogenesis to Gene Therapy Special Issue

, 2023
Muscular dystrophies (MDs) make up a clinically and genetically heterogeneous group of skeletal muscle diseases with progressive muscle weakness and atrophy [...
Luisa Politano, Filippo M. Santorelli
core   +1 more source

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

eLife
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD) whose genetic basis remains elusive, likely due to oligogenic complexity. To identify regulators of cardiomyocyte (CM) proliferation relevant to HLHS, we performed a
Tanja Nielsen, Anaïs Kervadec, Jeanne L Theis, Maria A Missinato, James Marchant, Michaela Romero, Katya Marchetti, Aashna Lamba, Xin-Xin I Zeng, Marie Berenguer, Stanley M Walls, Analyne Schroeder, Katja Birker, Greg Duester, Paul Grossfeld, Timothy J Nelson, Timothy M Olson, Karen Ocorr, Rolf Bodmer, Georg Vogler, Alexandre R Colas   +20 more
doaj   +1 more source

Variation of total antioxidant status after ischemic stroke [PDF]

Romanian Journal of Neurology, 2011
There is strong evidence that oxidative stress appears to be a major contributor to ischemic brain injury. Objective: To study dynamic evolution of Total Antioxidant Status (TAS) and other markers of oxidative stress after ischemic stroke and to fi nd ...
Ioana Varga, Iulian Ionescu
doaj   +1 more source

Musculoskeletal complications of Cushing syndrome

Rheumatology, 2023
Prolonged exposure to an excess of glucocorticosteroids (GCs), both endogenous and exogenous, leads to a wide range of comorbidities, including cardiovascular, metabolic, psychiatric, and musculoskeletal disorders.
Dorota Leszczyńska, Alicja Szatko, Lucyna Papierska, Wojciech Zgliczyński, Piotr Glinicki   +4 more
doaj   +1 more source

Tenascin-C from the tissue microenvironment promotes muscle stem cell maintenance and function through Annexin A2

Communications Biology
Skeletal muscle regeneration occurs through the finely timed activation of resident muscle stem cells (MuSC). Following injury, MuSC exit quiescence, undergo myogenic commitment, and regenerate the muscle.
Alessandra Cecchini, Mafalda Loreti, Collin D. Kaufman, Cedomir Stamenkovic, Gabriele Guarnaccia, Alma Renero, Chiara Nicoletti, Anais Kervadec, Daphne Mayer, Shawn Delaware, Luca Caputo, Xiuqing Wei, Alexandre Colas, Pier Lorenzo Puri, Alessandra Sacco   +14 more
doaj   +1 more source

The use of umbilical cord‐derived mesenchymal stem cells in patients with muscular dystrophies: Results from compassionate use in real‐life settings

Stem Cells Translational Medicine, 2021
Muscular dystrophies are genetically determined progressive diseases with no cause‐related treatment and limited supportive treatment. Although stem cells cannot resolve the underlying genetic conditions, their wide‐ranging therapeutic properties may ...
Beata Świątkowska‐Flis, Izabela Zdolińska‐Malinowska, Dominika Sługocka, Dariusz Boruczkowski   +3 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source