Results 41 to 50 of about 430,112 (309)

Pulmonary and Physical Rehabilitation in Critically Ill Patients [PDF]

Acute and Critical Care, 2019
Some patients admitted to the intensive care unit (ICU) because of an acute illness, complicated surgery, or multiple traumas develop muscle weakness affecting the limbs and respiratory muscles during acute care in the ICU.
Myung Hun Jang, Myung-Jun Shin, Yong Beom Shin   +2 more
doaj   +1 more source

Non-neural phenotype of spinal and bulbar muscular atrophy: Results from a large cohort of Italian patients [PDF]

, 2016
Objective: To carry out a deep characterisation of the main androgen-responsive tissues involved in spinal and bulbar muscular atrophy (SBMA). Methods: 73 consecutive Italian patients underwent a full clinical protocol including biochemical and hormonal ...
Angelini, Lorenzo, Bello, Luca, Bertolin, Cinzia, Briani, Chiara, Caretta, Nicola, Corrado, Domenico, da Re, Elisa, Ermani, Mario, Ferlin, Alberto, Foresta, Carlo, Gaiani, Alessandra, Galasso, Giuliana, Iafrate, Massimo, Mandrioli, Jessica, Mariotti, Caterina, Massa, Roberto, Mazzini, Letizia, Palmieri, Arianna, Pareyson, Davide, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Petrucci, Antonio, Polo, Alberto, Querin, Giorgia, Ricci, Giulia, Romito, Silvia, Sagnelli, Anna, Sartori, Leonardo, Scarpelli, Mauro, Semplicini, Claudio, Siciliano, Gabriele, Silani, Vincenzo, Silvano, Maria, Soraru', Gianni, Tonin, Paola, Volpe, Marco, Zara, Gabriella   +37 more
core   +1 more source

The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study. [PDF]

, 2013
IntroductionDuchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren.
Abresch, R Ted, Barth, Jay, Eagle, Michelle, Elfring, Gary, Florence, Julaine M, Gappmaier, Eduard, Glanzman, Allan M, Henricson, Erik K, McDonald, Craig M, Peltz, Stuart, PTC124-GD-007-DMD Study Group, Reha, Allen, Spiegel, Robert   +12 more
core   +2 more sources

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

eLife
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD) whose genetic basis remains elusive, likely due to oligogenic complexity. To identify regulators of cardiomyocyte (CM) proliferation relevant to HLHS, we performed a
Tanja Nielsen, Anaïs Kervadec, Jeanne L Theis, Maria A Missinato, James Marchant, Michaela Romero, Katya Marchetti, Aashna Lamba, Xin-Xin I Zeng, Marie Berenguer, Stanley M Walls, Analyne Schroeder, Katja Birker, Greg Duester, Paul Grossfeld, Timothy J Nelson, Timothy M Olson, Karen Ocorr, Rolf Bodmer, Georg Vogler, Alexandre R Colas   +20 more
doaj   +1 more source

Variation of total antioxidant status after ischemic stroke [PDF]

Romanian Journal of Neurology, 2011
There is strong evidence that oxidative stress appears to be a major contributor to ischemic brain injury. Objective: To study dynamic evolution of Total Antioxidant Status (TAS) and other markers of oxidative stress after ischemic stroke and to fi nd ...
Ioana Varga, Iulian Ionescu
doaj   +1 more source

Musculoskeletal complications of Cushing syndrome

Rheumatology, 2023
Prolonged exposure to an excess of glucocorticosteroids (GCs), both endogenous and exogenous, leads to a wide range of comorbidities, including cardiovascular, metabolic, psychiatric, and musculoskeletal disorders.
Dorota Leszczyńska, Alicja Szatko, Lucyna Papierska, Wojciech Zgliczyński, Piotr Glinicki   +4 more
doaj   +1 more source

Congenital muscular dystrophy: from muscle to brain. [PDF]

, 2016
Congenital muscular dystrophies (CMDs) are a wide group of muscular disorders that manifest with very early onset of muscular weakness, sometime associated to severe brain involvement.The histologic pattern of muscle anomalies is typical of dystrophic ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M, Vitaliti G   +7 more
core   +1 more source

Evaluation of earlier versus later dietary management in long-chain 3-hydroxyacyl-CoA dehydrogenase or mitochondrial trifunctional protein deficiency::a systematic review [PDF]

, 2019
Background: Mitochondrial trifunctional protein (MTP) and long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiencies are rare fatty acid β-oxidation disorders. Without dietary management the conditions are life-threatening. We conducted a systematic
Clarke, Aileen, Connock, Martin, Fraser, Hannah, Geppert, Julia, Johnson, Rebecca, Johnson, Samantha, Stinton, Christopher, Taylor-Phillips, Sian   +7 more
core   +2 more sources

Tenascin-C from the tissue microenvironment promotes muscle stem cell maintenance and function through Annexin A2

Communications Biology
Skeletal muscle regeneration occurs through the finely timed activation of resident muscle stem cells (MuSC). Following injury, MuSC exit quiescence, undergo myogenic commitment, and regenerate the muscle.
Alessandra Cecchini, Mafalda Loreti, Collin D. Kaufman, Cedomir Stamenkovic, Gabriele Guarnaccia, Alma Renero, Chiara Nicoletti, Anais Kervadec, Daphne Mayer, Shawn Delaware, Luca Caputo, Xiuqing Wei, Alexandre Colas, Pier Lorenzo Puri, Alessandra Sacco   +14 more
doaj   +1 more source

The use of umbilical cord‐derived mesenchymal stem cells in patients with muscular dystrophies: Results from compassionate use in real‐life settings

Stem Cells Translational Medicine, 2021
Muscular dystrophies are genetically determined progressive diseases with no cause‐related treatment and limited supportive treatment. Although stem cells cannot resolve the underlying genetic conditions, their wide‐ranging therapeutic properties may ...
Beata Świątkowska‐Flis, Izabela Zdolińska‐Malinowska, Dominika Sługocka, Dariusz Boruczkowski   +3 more
doaj   +1 more source