Results 101 to 110 of about 3,657,795 (294)

Investigation of Upper Limb Disorders and its Relationship with Physical Working Requirements among metallic industry Workers

Electronic Physician, 2012
Introduction: Musculoskeletal disorders, premature tiredness caused by work and so on are arisen from different requirements of every job. According to the statistics provided by the World Health Organization (WHO), the most important cause of the loss ...
Ehsanollah Habibi, Zahra Asaadi, Jamshid Khobi, Abdull Barkhordari, Karim Fard Zarei, Mohsen Karchani, Javad Vatani   +6 more
doaj  

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Investigation of Factors Affecting Musculoskeletal Disorders among Hospital Emergency Nurses of Qom University of Medical Sciences, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2016
Background and Objectives: Musculoskeletal disorders are one of the most common and costly occupational injuries, because they account for one-third of work-related injuries per year.
Mohsen Farahabadi, Zahra Aliakbarzade arani, Seyed Abdillah Chavoshizade, Akram Barati   +3 more
doaj  

How do musculoskeletal disorders impact on quality of life in Tanzania? Results from a community-based survey

BMJ Open
Objectives There are little available data on the prevalence, economic and quality of life impacts of musculoskeletal disorders in sub-Saharan Africa.
, Stefan Siebert, Emma McIntosh, Manuela Deidda, Sally Wyke, Richard Walker, Ping-Hsuan Hsieh, Blandina Mmbaga, Christopher Bunn, Mia Crampin, Clive Kelly, Kajiru Kilonzo, Eleanor Grieve, Jo Coast, Elizabeth F Msoka, Sanjura Mandela Biswaro, Febronia Shirima, Jo E B Halliday, Nateiya M Yongolo, Emma Laurie, Blandina Theophil Mmbaga, Jo Halliday, Stefanie J Krauth, Kiula P Kiula, Rose Kolimba, Nateiya Mmeta Yongolo, Sanjura Biswaro, Edith Chikumbu, Victor Katiti, Gloria Moshi, Elizabeth Msoka, Jennika Virhia   +31 more
doaj   +1 more source

Patterns of Radiologic Service Utilization and Imaging Expenditure in Supercentenarians in Colombia

AGING MEDICINE, EarlyView.
Analysis of Colombian administrative health data from 2014 to 2023 identified a distinct pattern of radiologic service utilization among supercentenarians (≥ 110 years). General radiology, ultrasound, and computed tomography were the most frequently used modalities, accounting for most imaging examinations.
Gabriela Puentes, Oscar Espinosa, Valeria Bejarano, Angela Guarnizo   +3 more
wiley   +1 more source

Fatigue‐Driven Adaptive Assistance for a Semi‐Active Upper‐Limb Occupational Exoskeleton

Advanced Intelligent Systems, EarlyView.
Physical fatigue during a physical activity is estimated in real time to enable adaptive exoskeleton assistance. By continuously adjusting the level of support according to the user’s fatigue, this approach reduces physical demand and provides a pathway toward personalized exoskeleton assistance.
Seemab Zakir, Lorenzo Grazi, Simone Prisinzano, Francesco Giovacchini, Nicola Vitiello, Emilio Trigili, Simona Crea   +6 more
wiley   +1 more source