Results 111 to 120 of about 160,084 (289)

Design of Equipment Rack with TRIZ Method to Reduce Searching Time in Change Over Activity (Case Study : PT. Jans2en Indonesia) [PDF]

, 2010
Janssen is a manufacturing plant that works in furniture assembly. Component shortages often occurs, it will cause the increase of work in process (WIP) in assembly section.
Hartini, Sri, Nugroho W P, Susatyo, Subekti K R, Dina   +2 more
core  

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Investigation of Upper Limb Disorders and its Relationship with Physical Working Requirements among metallic industry Workers

Electronic Physician, 2012
Introduction: Musculoskeletal disorders, premature tiredness caused by work and so on are arisen from different requirements of every job. According to the statistics provided by the World Health Organization (WHO), the most important cause of the loss ...
Ehsanollah Habibi, Zahra Asaadi, Jamshid Khobi, Abdull Barkhordari, Karim Fard Zarei, Mohsen Karchani, Javad Vatani   +6 more
doaj  

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Investigation of Factors Affecting Musculoskeletal Disorders among Hospital Emergency Nurses of Qom University of Medical Sciences, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2016
Background and Objectives: Musculoskeletal disorders are one of the most common and costly occupational injuries, because they account for one-third of work-related injuries per year.
Mohsen Farahabadi, Zahra Aliakbarzade arani, Seyed Abdillah Chavoshizade, Akram Barati   +3 more
doaj  

How do musculoskeletal disorders impact on quality of life in Tanzania? Results from a community-based survey

BMJ Open
Objectives There are little available data on the prevalence, economic and quality of life impacts of musculoskeletal disorders in sub-Saharan Africa.
, Stefan Siebert, Emma McIntosh, Manuela Deidda, Sally Wyke, Richard Walker, Ping-Hsuan Hsieh, Blandina Mmbaga, Christopher Bunn, Mia Crampin, Clive Kelly, Kajiru Kilonzo, Eleanor Grieve, Jo Coast, Elizabeth F Msoka, Sanjura Mandela Biswaro, Febronia Shirima, Jo E B Halliday, Nateiya M Yongolo, Emma Laurie, Blandina Theophil Mmbaga, Jo Halliday, Stefanie J Krauth, Kiula P Kiula, Rose Kolimba, Nateiya Mmeta Yongolo, Sanjura Biswaro, Edith Chikumbu, Victor Katiti, Gloria Moshi, Elizabeth Msoka, Jennika Virhia   +31 more
doaj   +1 more source