Results 101 to 110 of about 337,915 (292)

The Association of Anterior Pelvic Tilt Angle and Clinical Knee Outcomes among Patients with Patellofemoral Pain: A Cross-Sectional Study. [PDF]

Journal of Bioscience and Applied Research
Background: Patellofemoral Pain (PFP) is a frequent musculoskeletal disorder that affects young active subjects and the public. A significant contributing component to the etiology of PFP is an alteration of the lower limb kinetic chain.
Labib Ghali, Enas Youssef, Tarek Diab, Marihan Aziz   +3 more
doaj   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Evaluation of Musculoskeletal Disorders Risk Factors by REBA and QEC Methods in an Aluminum Industry [PDF]

, 2016
Background: Musculoskeletal disorders (MSDs) are the most common problems in workplaces. The present study assessed the prevalence of musculoskeletal disorders and the level of risk for these disorders among workers of an aluminum industry in Tehran ...
Fasih Ramandi, Fatemeh, Karamhkani, Morvarid, Moussavi Najarkola, Seyyed Ali, Nadri, Farshad, Nadri, Hamed   +4 more
core  

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Intracellular autofluorescence enables the isolation of viable, functional human muscle reserve cells with distinct Pax7 levels and stem cell states

Stem Cell Research & Therapy
Background Human muscle reserve cells (MuRC) represent a quiescent MuSC population generated in vitro that exhibit heterogeneous Pax7 expression, with a Pax7High subset in a deeper quiescent state. However, the conventional method of identifying Pax7High
Axelle Bouche, Diego Michel, Perrine Castets, Didier Hannouche, Thomas Laumonier   +4 more
doaj   +1 more source

Ergonomics in the Workplace: Is It Time for an OSHA Standard? [PDF]

, 2001
Improper ergonomic design of jobs is one of the leading causes of work-related illness, accounting for perhaps a third of employers’ costs under state workers’ compensation laws.
Rappaport, Edward
core   +5 more sources

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Hubungan Antara Postur Kerja Dengan Tingkat Keluhan Subyektif Muskuloskeletal Pada Penjaga Pintu Tol Tembalang Semarang [PDF]

, 2016
Muculoskeletal disorders are complaints on parts of the skeletal muscles that felt by someone start by minor disorders up to very sick. One of disease that affects many workers was musculoskeletal disorders, musculoskeletal disorders therefore an ...
Ekawati, E. (Ekawati), Suroto, S. (Suroto), Yustica, D. D. (Dhandy)   +2 more
core  

A Fully Self‐Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis

Advanced Science, EarlyView.
This study reports a system‐level fully self‐powered digital wearable system (FS‐DWS) for the auxiliary treatment of plantar fasciitis. By integrating arch support, energy harvesting, wearable sensing, and machine learning‐driven closed‐loop visualized feedback, the system enables effective plantar pressure reduction and self‐powered, real‐time plantar
Jiacheng Hou, Ying Hong, Shiyuan Liu, Qiqi Pan, Jingyu Zhang, Qingyang Xu, Qiyi Nie, Zhonghe Wang, Liming Xin, Yilong Wang, Biao Wang   +10 more
wiley   +1 more source