Results 101 to 110 of about 205,535 (299)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Part-time sick leave as a treatment method for individuals with musculoskeletal disorders [PDF]

There is increasing evidence that staying active is an important part of a recovery process for individuals on sick leave due to musculoskeletal disorders (MSDs). It has been suggested that using part-time sick-leave rather than full-time sick leave will
Svensson, Mikael, Andrén, Daniela
core  

Efficacy of adding manual therapy to hip and knee exercises in patients with patellofemoral pain syndrome: a double-blinded randomized controlled clinical trial

Scientific Reports
Patellofemoral pain syndrome (PFPS) is the most common knee problem that affects the knee in adulthood. It is more common in females twice than in males. It has a multifactorial etiology.
Nadia Abdo, Enas Fawzy Youssef, Mona Mohamed Ibrahim   +2 more
doaj   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Critical analysis of a Musculoskeletal Disorders Prevention Program [PDF]

, 2012
Critical analysis of a Musculoskeletal Disorders Prevention ProgramThe studies involving the development of occupational diseases and accidents at work prevention programs have delimited two facts.
Silveira, Lizandra da Silva, Cruz, Roberto Moraes, Merino, Eugenio Andrés Diaz, Silveira, Andréa Luiza da   +3 more
core  

The effectiveness of therapeutic ultrasound for musculoskeletal conditions of the lower limb: a literature review

, 2010
Background: Ultrasound is suggested as one of the treatment options available for soft tissue musculoskeletal conditions of the lower limb and to this end, the objective was to review the literature and evaluate the effectiveness of therapeutic ...
Fletcher, Paul, Paul Fletcher, Curran, Mike, Pippa Shanks, Richard Thompson, Michael Curran, Shanks, Pippa, Thompson, Richard   +7 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Back or neck-pain-related disability of nursing staff in hospitals, nursing homes and home care in seven countries- results from the European NEXT-Study [PDF]

, 2008
Background: musculoskeletal disorders are a widespread affliction in the nursing profession. Back or neck-pain-related disability of nursing staff is mainly attributed to physical and psychosocial risk factors.Objectives: to investigate which—and to what
Tackenberg, Peter, Conway, Paul Maurice, Simon, Michael, Hasselhorn, H.-M., Hasselhorn, H. -M., Nienhaus, Albert, Estryn-Behar, Madeleine   +6 more
core   +1 more source

The Association of Anterior Pelvic Tilt Angle and Clinical Knee Outcomes among Patients with Patellofemoral Pain: A Cross-Sectional Study. [PDF]

Journal of Bioscience and Applied Research
Background: Patellofemoral Pain (PFP) is a frequent musculoskeletal disorder that affects young active subjects and the public. A significant contributing component to the etiology of PFP is an alteration of the lower limb kinetic chain.
Labib Ghali, Enas Youssef, Tarek Diab, Marihan Aziz   +3 more
doaj   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source