Results 161 to 170 of about 3,812,603 (397)

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Intracellular autofluorescence enables the isolation of viable, functional human muscle reserve cells with distinct Pax7 levels and stem cell states

Stem Cell Research & Therapy
Background Human muscle reserve cells (MuRC) represent a quiescent MuSC population generated in vitro that exhibit heterogeneous Pax7 expression, with a Pax7High subset in a deeper quiescent state. However, the conventional method of identifying Pax7High
Axelle Bouche, Diego Michel, Perrine Castets, Didier Hannouche, Thomas Laumonier   +4 more
doaj   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Satisfied Workers, Retained Workers: Effects of Work and Work Environment on Homecare Workers' Job Satisfaction, Stress, Physical Health, and Retention [PDF]

The goal of this project was to assist health system managers and policy makers develop policies and strategies to recruit and retain human resources in the homecare sector and have a satisfied, healthy workforce.
Isik U. Zeytinoglu, Margaret Denton
core   +3 more sources

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Ergonomic Assessment of Workstations and Musculoskeletal Disorders Risk Assessment in the Central Oil Refinery Workshop of Hormozgan Province [PDF]

, 2015
Background: Working station includes the physical environment and arrangement of all equipment in the work place. Work-related musculoskeletal disorders are among the most common occupational injuries.
Asadi, Masumeh, Feyzi, Vafa, Ghafori, Sahand, Ghotbi Ravandi, Mohammad Reza, Mehdipoor, Shayan   +4 more
core  

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Is there a subgroup of females with patellofemoral pain syndrome likely to benefit from proximal control exercises?

Physiotherapy Quarterly
Introduction Patellofemoral pain syndrome (PFPS) is one of the most popular complaints among young females. Proximal hip control exercises can improve hip strength and reduce the stresses and pain.
Khaled A. Shalash, Abd El Rahman Chabara, Ahmad Hamdi Azzam, Nabil A. Mohamed, Ahmed M. ElMelhat   +4 more
doaj   +1 more source

SIGNS OF CENTRAL SENSITIZATION IN PATIENTS WITH MUSCULOSKELETAL DISORDERS AND CHRONIC COMORBIDITIES: A SYSTEMATIC REVIEW AND META-ANALYSES OF OBSERVATIONAL STUDIES [PDF]

, 2023
Mattia Sgarbi, Davide D’Alessandro, Matteo Castaldo, Daniel Feller   +3 more
openalex   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source