Results 31 to 40 of about 494,284 (266)

The impact of tool selection on back and wrist injury risk in tying steel reinforcement bars: a single case experiment [PDF]

, 2019
The paper explores the risk of work-related musculoskeletal injury in tying steel reinforcement bars. Three tools are compared to determine the extent to which ergonomic tools can reduce the risk of injury to the back and wrist in steel-tying.
Fitzgerald, Chris, Lingard, Helen, Lythgo, Noel, Selva Raj, Isaac, Troynikov, Olga   +4 more
core   +2 more sources

Targeted Overexpression of Claudin 11 in Osteoblasts Increases Trabecular Bone Mass by Stimulating Osteogenesis at the Expense of Adipogenesis in Mice

Biology
Mice lacking Claudin11 (Cldn11) manifest reduced trabecular bone mass. However, the impact of Cldn11 expression in osteoblasts in vivo remains understudied. Herein, we generated osteoblast-specific transgenic (Tg) mice expressing Cldn11 and characterized
Weirong Xing, Sheila Pourteymoor, Anakha Udayakumar, Yian Chen, Subburaman Mohan   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Enhanced Bone Formation in Segmental Defect Healing Using 3D Printed Scaffolds Containing Bone Marrow Stromal Cells and Small Molecules Targeting Chondrogenesis and Osteogenesis

Biomedicines
Background/Objectives: Nonunion bone healing results from a critical size defect that fails to bridge a bone injury to produce bony union. Novel approaches are critical for refining therapy in clinically challenging bone injuries, but the complex and ...
Charles H. Rundle, Sheila Pourteymoor, Enoch Lai, Chandrasekhar Kesavan, Subburaman Mohan   +4 more
doaj   +1 more source

Designing optimal controls by parameter optimization for a stance-control knee-ankle-foot orthosis [PDF]

, 2014
Inverse dynamics simulation is often used in robotic and mechatronic systems to track a desired trajectory by feed-forward control. Musculoskeletal multibody systems are highly overactuated and show a switching number of closed kinematical loops.
Font Llagunes, Josep Maria, García-Vallejo, Daniel   +1 more
core  

Real-time simulation of three-dimensional shoulder girdle and arm dynamics [PDF]

, 2014
Electrical stimulation is a promising technology for the restoration of arm function in paralyzed individuals. Control of the paralyzed arm under electrical stimulation, however, is a challenging problem that requires advanced controllers and command ...
Blana, D, Chadwick, EK, Kirsch, RF, van den Bogert, AJ   +3 more
core   +3 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Direct solution of the inverse optimization problem of load sharing between muscles

, 2006
In the context the statically indeterminate muscular load sharing problem considered in biomechanics of the musculoskeletal system, a method is suggested of constructing an additively separable and homogenous cost function based on a solution to a ...
Siemienski, Adam
core   +1 more source

Hip Morphology–Based Osteoarthritis Risk Prediction Models: Development and External Validation Using Individual Participant Data From the World COACH Consortium

Arthritis Care &Research, EarlyView.
Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Jinchi Tang, Harbeer Ahedi, Nigel K. Arden, Sita M. A. Bierma‐Zeinstra, Cindy G. Boer, Flavia M. Cicuttini, Timothy F. Cootes, David T. Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E. Lane, Claudia Lindner, Joyce B. J. van Meurs, Andrea Mosler, Amanda E. Nelson, Michael C. Nevitt, Edwin H. Oei, Jos Runhaar, Harrie Weinans, Jesse H. Krijthe, Rintje Agricola   +26 more
wiley   +1 more source

Analysis of Required Investigations of Work-Related Musculoskeletal Disorders in Spain [PDF]

, 2019
Musculoskeletal disorders (MSD) are the most common source of occupational health problems in Western countries. In Spain, musculoskeletal disorders (MSDs) can be reported either as accidents or occupational diseases.
Carrillo-Castrillo, Jesús Antonio, Pardo Ferreira, María del Carmen, Pérez Mira, Ventura, Rubio-Romero, Juan Carlos   +3 more
core