Results 281 to 290 of about 136,223 (377)

The Dewar photoproduct of thymidylyl(3′→5′)- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the “A rule”

, 2000
Joon‐Hwa Lee, Sung-Hun Bae, Byong‐Seok Choi   +2 more
openalex   +2 more sources

Phase 1 Dose Escalation of Single‐Agent Mechlorethamine in Dogs With Lymphoma

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 51-57, March 2026.
ABSTRACT Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose (MTD) of mechlorethamine in dogs with lymphoma.
Laura E. Chadsey, Paul R. Hess, Joanne L. Intile   +2 more
wiley   +1 more source

On the Utilization and Characterization of External Biotransformation Systems in <i>In Vitro</i> Toxicology: A Critical Review of the Scientific Literature with Guidance Recommendations. [PDF]

ACS Environ Au
Lungu-Mitea S, Stein Åslund M, Reichstein I, Pinto-Vidal FA, Schiwy A, Hollert H, Jacobs MN, Hilscherová K.   +7 more
europepmc   +1 more source

Identification of mutagenic substances in roselle color, elderberry color and safflower yellow.

, 1985
Nobuyuki Takeda, Yohko Yasui
openalex   +2 more sources

Direct Identification and Quantification of Flavonoids and Their Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 3, 15 February 2026.
ABSTRACT Rationale Flavonoids are phenolic compounds with many health‐benefiting properties. However, differentiating different types of flavonoids and their isomers is challenging due to their highly similar structures of various subtypes and different numbers and sites of substituents.
Yanqiu Wang, Liping Xu, Tiange Gu, Hongli Li, David Da Yong Chen   +4 more
wiley   +1 more source

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate. [PDF]

Genes Environ
Matsumoto M, Natsume M, Iso T, Umano T, Murata Y, Masumura K, Horibata K, Sugiyama KI.   +7 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, Volume 16, Issue 2, Page 365-381, February 2026.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

<i>In</i> silico toxicological risk assessment of chemical constituents from <i>Curtisia dentata</i> stem-bark extract. [PDF]

Toxicol Rep
van Wyk AS, Ojo O, Bodede O, Prinsloo G.
europepmc   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, Volume 9, Issue 2, February 2026.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source