Results 101 to 106 of about 291 (106)

The Genetic Toxicity of Polycyclic Aromatic Hydrocarbons: A Cross-Tissue, Multi-Endpoint Study in the Transgenic MutaMouse

2017
Polycyclic aromatic hydrocarbons (PAHs) are produced via the incomplete combustion of organic matter. They are ubiquitously present in the environment, and human exposures typically involve complex PAH mixtures in complex matrices (e.g., soil, urban air).
openaire   +2 more sources

Partial hepatectomy strongly increased the mutagenicity of N‐ethyl‐N‐nitrosourea in Muta™Mouse liver

Environmental and Molecular Mutagenesis, 1999
The relationship between cell proliferation and mutagenesis can be investigated in vivo due to the advent of transgenic animal mutation assays. In these assays, slowly proliferating tissues, such as mammary gland and liver, that are exposed to mutagens generally have longer manifestation times for mutations and lower mutant frequencies.
T, Hara, H, Sui, K, Kawakami, Y, Shimada, T, Shibuya   +4 more
openaire   +2 more sources

In vivo mutagenesis as detected at the lacZ locus in MutaMouse

Mutation Research/Environmental Mutagenesis and Related Subjects, 1992
B. Myhr, D.J. Kirkland
openaire   +1 more source

Validation of an In Vitro Mutagenicity Assay Based on Pulmonary Epithelial Cells from the Transgenic MutaMouse: Intra-Laboratory Variability and Metabolic Competence

2018
Genetic toxicity tests used for regulatory screening must be rigorously validated to ensure accuracy, reliability and relevance. Hence, prior to establishment of an internationally-accepted test guideline, a new assay must undergo multi-stage validation.
openaire   +2 more sources

Analytical method for mutations in vivo at the lacZ locus in MutaMouse tissues

Mutation Research/Environmental Mutagenesis and Related Subjects, 1992
B. Myhr, H. Khouri, K. Intehar, L. Custer, T. Suzuki   +4 more
openaire   +1 more source

Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model

2008
Mahabir, AG, van Benthem, Jrivm, Korsten, H, Lynch, AM, Bailey, L, de Vries, Arivm, Hendriksen, CFM, van Steeg, Hrivm   +7 more
openaire   +1 more source