Results 91 to 100 of about 260 (125)

SOME IDEAS ABOUT MUTAMOUSE AS A POSSIBLE TOOL FOR STUDYING IN VIVO INDUCTION OF GENE MUTATIONS

, 1993
Philip Morris Records
core  

Ambient aromatic hydrocarbons and prostate cancer: mechanistic evidence linking benzene and PAH exposure to tumor progression. [PDF]

Front Cell Dev Biol
Wu H, Cao H, Ye Z, Li Z, Chang M, Zhang W, Xu T, Wang L, Yang T, Deng X, Hu E, Gao B.   +11 more
europepmc   +1 more source

Mutagenicity, the effects on DNA damage, ROS levels and the cell cycle in the Mutamouse lung epithelial cell line

, 2008
Korsholm, K., Saber, A. T., Loft, S., White, P. A., Jacobsen, N. R., Wallin, H., Møller, P., Cohn, C., Vogel, Ulla Birgitte   +8 more
core  

A Systematic Genotoxicity Assessment of a Suite of Metal Oxide Nanoparticles Reveals Their DNA Damaging and Clastogenic Potential. [PDF]

Nanomaterials (Basel)
Solorio-Rodriguez SA, Wu D, Boyadzhiev A, Christ C, Williams A, Halappanavar S.   +5 more
europepmc   +1 more source

Folate deficiency increases chromosomal damage and mutations in hematopoietic cells in the transgenic mutamouse model [PDF]

Environmental and Molecular Mutagenesis, 2018
Folate deficiency causes megaloblastic anemia and neural tube defects, and is also associated with some cancers. In vitro, folate deficiency increases mutation frequency and genome instability, as well as exacerbates the mutagenic potential of known environmental mutagens.
Jason M. O'Brien, Amanda J MacFarlane, Francesco Marchetti   +2 more
exaly   +4 more sources

Folate Intake Alters Mutation Frequency and Profiles in a Tissue- and Dose-Specific Manner in MutaMouse Male Mice.

Journal of Nutrition, 2021
While cancer is common, its incidence varies widely by tissue. These differences are attributable to variable risk factors, such as environmental exposure, genetic inheritance, and lifetime number of stem cell divisions in a tissue. Folate deficiency is generally associated with increased risk for colorectal cancer (CRC) and acute lymphocytic leukemia (
Alex Yu Hin Wong, Amanda J MacFarlane, Francesco Marchetti   +2 more
exaly   +4 more sources

Poly(ethylene imine) Nanocarriers Do Not Induce Mutations nor Oxidative DNA Damage in Vitro in MutaMouse FE1 Cells

Molecular Pharmaceutics, 2011
Genotoxicity information on polymers used for gene delivery is scant, but of great concern, especially when developing polymeric nanocarriers as nonviral vector systems for cancer treatment. The genotoxicity of some engineered nanomaterials, e.g., metal oxides like ZnO, TiO₂, and CuO but also carbon based materials like carbon black or nanotubes, has ...
Paul White, Alexandra S Long, Tobias Stoeger   +2 more
exaly   +4 more sources

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In vivo mutagenesis as detected at the lacZ locus in MutaMouse

Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology, 1992
D J Kirkland
exaly   +2 more sources

The cII locus in the MutaMouse System

Environmental and Molecular Mutagenesis, 1999
Here, we report the first application and characterization of the cII locus as a mutational target for use with the Muta(trade mark)Mouse system for quantifying somatic mutations in vivo. This locus can be analyzed for mutations using positive selection and is identical in sequence to the cII in the Big Blue((R)) Mouse.
R R, Swiger, L, Cosentino, N, Shima, J H, Bielas, W, Cruz-Munoz, J A, Heddle   +5 more
openaire   +2 more sources

Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model

Toxicology and Applied Pharmacology, 2018
The Organisation for Economic Co-operation and Development (OECD) endorses test guidelines (TG) for identifying chemicals that are genotoxic, such as the transgenic rodent gene mutation assay (TG 488). Current OECD TG do not include assays for sperm DNA damage resulting in a critical testing gap.
Jason M. O'Brien, Carole Yauk, Francesco Marchetti   +2 more
exaly   +3 more sources