Results 101 to 110 of about 260 (125)

Is Muta™Mouse insensitive to clastogens?

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008
Several studies suggest that MutaMouse is insensitive to clastogens, including the accompanying paper by Mahabir et al., which describes a study with bleomycin, camptothecin, m-AMSA (4'-(9-acridinylamino)-methanesulfon-m-anisidide) and its ortho-analogue, o-AMSA (4'-(9-acridinylamino)-methanesulfon-o-anisidide).
Lynch, AM, Mahabir, AG, Bradford, A, Brockhurst, K, van Benthem, Jrivm, van Steeg, Hrivm, Rees, RW   +6 more
openaire   +5 more sources

Toxicity Profile of Benzo[a]pyrene in the MaleLacZTransgenic Mouse (MutaMouse) Following Oral Administration for 5 Consecutive Days

Regulatory Toxicology and Pharmacology, 1998
The toxicity profile of benzo[a]pyrene (BP) was examined in the MutaMouse. The transgenic mouse integrated with lambda gt10 lacZ vectors is used worldwide as an experimental animal in in vivo mutagenesis testing systems. There are few toxicity studies including carcinogenicity in the MutaMouse, and so far only a few carcinogenicity studies of BP ...
A, Hakura, J, Sonoda, Y, Tsutsui, T, Mikami, T, Imade, M, Shimada, S, Yaguchi, M, Yamanaka, M, Tomimatsu, K, Tsukidate   +9 more
openaire   +2 more sources

Mutagenicity of 4-nitroquinoline 1-oxide in the Muta™Mouse

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
As part of a collaborative study, the Mammalian Mutagenesis Study Group (MMS), a sub-organization of the Environmental Mutagen Society of Japan (JEMS) conducted mutagenicity tests in MutaMouse. Using a positive selection method, we studied the organ-specificity and time dependence of mutation induction by 4-nitroquinoline 1-oxide (4NQO).
M, Nakajima, M, Kikuchi, K, Saeki, Y, Miyata, M, Terada, F, Kishida, R, Yamamoto, C, Furihata, S W, Dean   +8 more
openaire   +2 more sources

In vivo genotoxicity evaluation of dimethylarsinic acid in Muta™Mouse

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2002
Dimethylarsinic acid (DMA) induces DNA damage in the lung by formation of various peroxyl radical species. The present study was conducted to evaluate whether arsenite or its metabolite, DMA, could initiate carcinogenesis via mutagenic DNA lesions in vivo that can be attributed to oxidative damage.
Yasuhiro, Noda, Takayoshi, Suzuki, Arihiro, Kohara, Akira, Hasegawa, Toshihisa, Yotsuyanagi, Makoto, Hayashi, Toshio, Sofuni, Kenzo, Yamanaka, Shoji, Okada   +8 more
openaire   +2 more sources

The LacZ transgene in mutaTM Mouse maps to chromosome 3

Mutation Research Letters, 1994
Transgenic mouse models are being used with increasing frequency for mutational and toxicological studies. One such system. MutaMouse, contains a stably integrated lambda-gt10LacZ shuttle vector in the mouse genome. We describe the use of dual color fluorescence in situ hybridization (FISH) with Mus musculus whole chromosome paints and lambda DNA to ...
R R, Swiger, B, Myhr, J D, Tucker
openaire   +2 more sources

Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (Muta™Mouse)

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2002
Aristolochic acid (AA) is found in a plant that causes urothelial carcinomas in patients with Chinese herb nephropathy (CHN). To evaluate the in vivo mutagenicity of AA, we analysed the mutant frequency (MF) in the lacZ and cII gene of 10 organs of the lambda/lacZ transgenic mouse (MutaMouse) after intragastric treatment with AA (15mg/kg per week x 4).
Arihiro, Kohara, Takayoshi, Suzuki, Masamitsu, Honma, Tomohiko, Ohwada, Makoto, Hayashi   +4 more
openaire   +2 more sources

Tissue‐specific metabolic activation and mutagenicity of 3‐nitrobenzanthrone in Muta™Mouse

Environmental and Molecular Mutagenesis, 2008
Abstract3‐Nitrobenzanthrone (3‐NBA) is a mutagen and suspected human carcinogen detected in diesel exhaust, airborne particulate matter, and urban soil. We investigated the tissue specific mutagenicity of 3‐NBA at the lacZ locus of transgenic Muta™Mouse following acute single dose or 28‐day repeated‐dose oral administration.
Guosheng, Chen, John, Gingerich, Lynda, Soper, George R, Douglas, Paul A, White   +4 more
openaire   +2 more sources

Mutation induction by N-propyl-N-nitrosourea in eight Muta™Mouse organs

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
As a part of the 2nd Collaborative Study for the Transgenic Mouse Mutation Assay, we studied the organ specificity and the temporal changes in mutant frequency (MF) of the lacZ gene following intraperitoneal injection of 250 mg/kg N-propyl-N-nitrosourea into male MutaMouse.
T, Hara, K, Hirano, N, Hirano, H, Tamura, H, Sui, T, Shibuya, A, Hyogo, T, Hirashio, H, Tokai, Y, Yamashita, K, Kura   +10 more
openaire   +2 more sources

Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in Muta?Mouse

Environmental and Molecular Mutagenesis, 1999
The mutagenicity and clastogenicity of the immunosuppressive drug azathioprine (AZA), a multitissue rodent carcinogen and IARC-classified human carcinogen, was investigated using transgenic lacZ mice (MutaMouse). Male animals (n = 5 per group) were dosed with AZA (10, 50, 100 mg/kg p.o.
C C, Smith, G E, Archer, E J, Forster, T R, Lambert, R W, Rees, A M, Lynch   +5 more
openaire   +2 more sources

Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of Muta ™Mouse transgenic mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
The human carcinogen 4-aminobiphenyl (4AB) was evaluated in the MutaMouse transgenic mouse mutation assay. A single oral dose of 75 mg/kg induced 6.9-, 1.8- and 2.2-fold increases in the mutation frequency (MF) in the bladder, liver and bone marrow, respectively.
K, Fletcher, H, Tinwell, J, Ashby
openaire   +2 more sources