Results 71 to 80 of about 260 (125)

Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment. [PDF]

Regul Toxicol Pharmacol
Yauk CL, Lynch AM, Dobrovolsky VN, Schuler M, Smith-Roe SL, Fitzgerald D, Higgins J, Honarvar N, Le Curieux F, Matsumura S, Minocherhomji S, Recio L, Salk JJ, Sugiyama KI, Suzuki T, Wills JW, Marchetti F.   +16 more
europepmc   +1 more source

Evaluation of the Toxicity of Coplanar PCBs Using Trangenic Mice(Research Group 4) [PDF]

内分泌撹乱物質は,母体を経由し胎子へ移行することがあり,その影響が危惧されている。本研究は,多数存在する内分泌撹乱物質の中でも,生体への影響が指摘されているCo-PCBs(PCB126: 3,3',4,4',5-pentachlorobiphenyl)について,子宮内暴露に伴うマウス胎子遺伝子に及ぼす影響や,次世代マウスの発育と行動に及ぼす影響について調べた。10～12週齢のMutaMouse(大腸菌lacZ遺伝子をトランスジェニックしたマウス)の雌雄を交配させ,腟栓が確認された日を妊娠0日目とし ...
猪股, 智夫, Inomata, Tomoo, イノマタ, トモオ   +2 more
core  

Poor Reporting Quality in Basic Nutrition Research: A Case Study Based on a Scoping Review of Recent Folate Research in Mouse Models (2009-2021). [PDF]

Adv Nutr, 2022
Munezero E, Behan NA, Diaz SG, Neumann EM, MacFarlane AJ.   +4 more
europepmc   +1 more source

New Approach Methods in Genetic Toxicology. [PDF]

Environ Mol Mutagen
Roberts DJ, Bryce SM.
europepmc   +1 more source

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis. [PDF]

Arch Toxicol
Ashford AL, Nachmanson D, Wills JW, Higgins JE, Smith TH, Vavra KC, Dahalan FA, Howe J, Elloway JM, Salk JJ, Doherty A, Lynch AM.   +11 more
europepmc   +1 more source

Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis. [PDF]

Arch Toxicol
Simon S, Schlingemann J, Johnson G, Brenneis C, Guessregen B, Kostal J, Dieckhoff J.   +6 more
europepmc   +1 more source

Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile. [PDF]

Chem Res Toxicol, 2020
Walker VE, Walker DM, Ghanayem BI, Douglas GR.   +3 more
europepmc   +1 more source

Dose-Related Mutagenic and Clastogenic Effects of Benzo[b]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay. [PDF]

Environ Sci Technol
Schuster DM, LeBlanc DPM, Zhou G, Meier MJ, Dodge AE, White PA, Long AS, Williams A, Hobbs C, Diesing A, Smith-Roe SL, Salk JJ, Marchetti F, Yauk CL.   +13 more
europepmc   +1 more source

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations. [PDF]

Mutagenesis
Lynch AM, Howe J, Hildebrand D, Harvey JS, Burman M, Harte DSG, Chen L, Kmett C, Shi W, McHugh CF, Patel KK, Junnotula V, Kenny J, Haworth R, Wills JW.   +14 more
europepmc   +1 more source

Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK). [PDF]

Chem Res Toxicol
Jolly RA, Noteboom J, LeBlanc DPM, Marchetti F, Cavanagh KL, Minocherhomji S.   +5 more
europepmc   +1 more source