Results 61 to 70 of about 260 (125)

Assessing the genotoxicity of N‐nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild‐type C57BL/6N mice

Environmental and Molecular Mutagenesis, Volume 65, Issue 6-7, Page 190-202, July‐August 2024.
Abstract The detection of N‐nitrosamines in drug products has raised global regulatory interest in recent years due to the carcinogenic potential of some nitrosamines in animals and a need to identify a testing strategy has emerged. Ideally, methods used would allow for the use of quantitative analysis of dose–response data from in vivo genotoxicity ...
Shaofei Zhang, Stephanie L. Coffing, William C. Gunther, Michael L. Homiski, Richard A. Spellman, Phu Van, Maik Schuler   +6 more
wiley   +1 more source

Mutation calls by SMM-Seq of MutaMouse male liver exposed to Benzo(B)Fluoranthene for 28 days

MutaMouse males were exposed to five doses of Benzo(B)Fluoranthene (BbF) alongside vehicle controls by oral gavage for 28 days with a 3 day sampling time. Random whole-genome sequencing of liver DNA was performed using MutagenTech's SMM-Seq.
Meier, Matthew
core   +1 more source

Harnessing New Genomics Technologies to Assess Environmental Risk Factors That May Cause Heritable Genetic Disease

, 2017
It is becoming increasingly apparent that heritable mutations play a major role in developmental disorders, yet we still know little about the role of environmental agents in the etiology of heritable mutations.
Beal, Marc Andrew
core   +1 more source

Mutations in the lacZ gene

This is the raw data representing 6,465 independent lacZ mutations from multiple MutaMouse experiments. We curated lacZ mutations from published studies that were collected using a positive selection assay to identify mutations in lacZ that disrupted β ...
Meier, Matthew
core   +1 more source

In Utero Exposure to Benzo [a] pyrene Results in Ovarian Follicular Depletion in F1 MutaTM mouse [PDF]

, 2016
OF THE THESISBySanjiwani MehardaMaster of Science in Environmental Health ScienceUniversity of California, Irvine,2016Professor Ulrike Luderer, Chair In contrast to gametogenesis in males, oocytes in females are not continually replenished during ...
Meharda, Sanjiwani
core  

The functional mutational landscape of the lacZ gene. [PDF]

iScience, 2023
Beal MA, Meier MJ, Dykes A, Yauk CL, Lambert IB, Marchetti F.   +5 more
europepmc   +1 more source

Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood. [PDF]

Environ Mol Mutagen
Zhang X, Hobbs CA, Rivas MV, Diesing A, LeBlanc DPM, Zhou G, Foley JF, White PA, Marchetti F, Yauk CL, Smith-Roe SL.   +10 more
europepmc   +1 more source

Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern. [PDF]

Arch Toxicol
Wills JW, White A, Harte DSG, Buckley R, Harvey JS, Lynch AM.   +5 more
europepmc   +1 more source

MutSeqR: an open source R package for standardized analysis of error-corrected next-generation sequencing data in genetic toxicology. [PDF]

Bioinform Adv
Dodge AE, Williams A, LeBlanc DPM, Schuster DM, Esina E, Valentine CC, Salk JJ, Maslov AY, Bradley C, Yauk CL, Marchetti F, Meier MJ.   +11 more
europepmc   +1 more source

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†. [PDF]

Biol Reprod
LeBlanc DPM, Zhou G, Williams A, Meier MJ, Valentine CC, Salk JJ, Yauk CL, Marchetti F.   +7 more
europepmc   +1 more source