Results 41 to 50 of about 260 (125)

Investigating the Mutagenicity of Polycyclic Aromatic Compounds from the Athabasca Oil Sands Region in River Otters and a Mammalian Cell Line [PDF]

, 2022
Mining operations have led to an increase in polycyclic aromatic compound (PAC) concentrations in the Alberta oil sands area. However, the toxicity of most PACs and PAC mixtures is not well characterized.
Gyasi, Helina
core   +1 more source

Re-assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials. [PDF]

EFSA J
Abstract The EFSA Panel on Food Contact Materials (FCM) was requested by the European Commission to re‐evaluate the potential genotoxicity of styrene after oral exposure and its safety for use in plastic FCM with a specific migration limit (SML) of 40 μg/kg food.
EFSA Panel on Food Contact Materials (FCM), Claude L, Crebelli R, Da Silva M, Grob K, Lampi E, Milana MR, Pronk M, Ščetar M, Theodoridis G, Van Hoeck E, Waegeneers N, Bolognesi C, Di Consiglio E, Mengelers M, Al Harraq Z, Pilar IM, Rainieri S, Rivière G.   +18 more
europepmc   +2 more sources

Scientific opinion on the renewal of the authorisation of Scansmoke SEF7525 (SF‐004) as a smoke flavouring Primary Product

EFSA Journal, Volume 21, Issue 11, November 2023., 2023
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product Scansmoke SEF7525 (SF‐004), for which a renewal application was submitted in accordance with Article 12(1) of Regulation (EC) No 2065/2003.
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Ullrika Sahlin, Maria Carfì, Edoardo Carnesecchi, Carla Martino, Agnieszka Mech, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +31 more
wiley   +1 more source

Scientific opinion on the renewal of the authorisation of SmokEz C‐10 (SF‐005) as a smoke flavouring Primary Product

EFSA Journal, Volume 21, Issue 11, November 2023., 2023
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product SmoKEz C‐10 (SF‐005), for which a renewal application was submitted in accordance with Article 12(1) of Regulation (EC) No 2065/2003.
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Gisela Degen, Ullrika Sahlin, Maria Carfì, Carla Martino, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +30 more
wiley   +1 more source

Mutations in the lacZ gene

, 2023
This is the raw data representing 6,465 independent lacZ mutations from multiple MutaMouse experiments. We curated lacZ mutations from published studies that were collected using a positive selection assay to identify mutations in lacZ that disrupted β ...
Meier, M (via Mendeley Data)
core   +1 more source

The mutagenic activity of select azo compounds in MutaMouse target tissues in vivo and primary hepatocytes in vitro

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2019
The mutagenicity of Direct Black 38, Sudan I, and Para Red were evaluated in the in vivo MutaMouse assay and the in vitro MutaMouse primary hepatocyte (PH) assay. Direct Black 38 is an International Agency for Research on Cancer (IARC) Group 1 carcinogen and a prototypical benzidine-based azo compound that requires azo-reduction to yield a DNA-reactive
Julie A, Cox, Paul A, White
openaire   +2 more sources

Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing. [PDF]

Environ Mol Mutagen
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Zhang S, Parsons BL, Fitzgerald D, Ashford A, Auman JT, Chen T, Dodge A, Elhajouji A, Pfaller L, Harris S, Higgins J, Hobbs CA, Marchetti F, Meier MJ, Myers MB, Salk J, Sahroui R, Schuster D, Settivari R, Smith-Roe SL, Yauk CL, Yan J, Williams A, Chen CL.   +23 more
europepmc   +2 more sources

In-Depth Characterization of Somatic and Germ Cell Mutagenic Response to Procarbazine Hydrochloride by Novel Error Corrected Sequencing [PDF]

, 2023
Assessment of chemical mutagenicity is essential to protecting human health from genetic disease. Current assays are limited in their ability to provide mechanistic insight into the endogenous and exogenous processes involved in mutagenesis.
Dodge, Annette
core   +1 more source

Evaluation of Strategies to Improve In Vitro Mutagenicity Assessment: Alternative Sources of S9 Exogenous Metabolic Activation and the Development of an In Vitro Assay Based on MutaMouse Primary Hepatocytes

, 2019
In vitro genetic toxicity tests using cultured bacterial or mammalian cells provide a cost- and time-effective alternative to animal tests. Unfortunately, existing in vitro assays are not always reliable.
Cox, Julie
core   +1 more source

Folate induced mutagenesis and identification of folate-specific mutation spectra in somatic cells [PDF]

, 2019
Folate is an essential water soluble B-vitamin required for the de novo synthesis of purines and dTMP and the synthesis of methionine. Folate intake,, generally folate deficiency, has been associated with CRC and ALL risk.
Diaz Gonzalez, Stephanie Andrea
core   +1 more source