Results 31 to 40 of about 260 (125)

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals. [PDF]

Arch Toxicol, 2021
AbstractThe Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is optimized for rapidly proliferating tissues such
Marchetti F, Zhou G, LeBlanc D, White PA, Williams A, Yauk CL, Douglas GR.   +6 more
europepmc   +4 more sources

Temporal analyses of germ cell mutations using the MutaMouse model support the recommended design in OECD test guideline 488. [PDF]

Arch Toxicol
Abstract The Organisation for Economic Co-operation and Development test guideline (TG) 488 uses transgenic rodent models to assess in vivo mutagenesis. TG 488 recommends 28 consecutive days of exposure with sampling of germ cells from seminiferous tubules 28 days post-exposure (i.e., 28 + 28d).
Zhou G, Williams A, LeBlanc DPM, Douglas GR, Yauk CL, Marchetti F.   +5 more
europepmc   +3 more sources

Investigation of mutagenicity of styrene in tumor target and non-target tissues of transgenic Big Blue® mice. [PDF]

Environ Mol Mutagen
Abstract Styrene has been shown to induce lung tumors in mice, but not in rats. The current study investigated the potential role of genotoxicity as an initial key event in the mode of action for styrene‐induced lung tumors in mice. Transgenic male B6C3F1 Big Blue® mice were treated by oral gavage for 28 consecutive days with 0 (corn oil), 75, 150, or ...
Gollapudi BB, Philp K, Weinberg JT.
europepmc   +2 more sources

In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses That Deplete Ovarian Follicles in Mice. [PDF]

Environ Mol Mutagen, 2019
Polycyclic aromatic hydrocarbons like benzo[a]pyrene (BaP) are ubiquitous environmental contaminants formed during incomplete combustion of organic materials.
Luderer U, Meier MJ, Lawson GW, Beal MA, Yauk CL, Marchetti F.   +5 more
europepmc   +2 more sources

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints. [PDF]

Environ Mol Mutagen
ABSTRACT The benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
White PA, Chen G, Chepelev N, Bell MA, Gallant LR, Johnson GE, Zeller A, Beal MA, Long AS.   +8 more
europepmc   +2 more sources

Transferability and Reproducibility of the HepaRG CometChip Assay. [PDF]

Environ Mol Mutagen
ABSTRACT This interlaboratory evaluation of HepaRG CometChip was conducted to assess transferability and reproducibility of this new approach methodology (NAM) across four laboratories. Concentrations inducing up to ~70% relative cytotoxicity were determined by the organizing laboratory, and frozen chemical formulation blocks were sent to each ...
Recio L, Swartz C, Martin L, Rottinger E, Pfuhler S, Pinkus E, Roberts DJ, Stankowski LF, Kaushal S, Owiti NA, Engelward BP.   +10 more
europepmc   +2 more sources

Scientific opinion on the renewal of the authorisation of proFagus Smoke R714 (SF‐001) as a smoke flavouring Primary Product

EFSA Journal, Volume 21, Issue 11, November 2023., 2023
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product proFagus Smoke R714 (SF‐001), for which a renewal application was submitted in accordance with Article 12(1) of Regulation (EC) No 2065/2003.
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Ullrika Sahlin, Maria Carfì, Blanka Halamoda, Agnieszka Mech, Carla Martino, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +31 more
wiley   +1 more source

Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung. [PDF]

Toxicol Sci
Abstract Clonal expansion (CE) of cells carrying cancer driver mutations (CDMs) is being developed as a biomarker of cancer risk. CE in lung of MutaMouse males treated with 0, 6.25, 12.5, and 25 mg/kg/d benzo[b]fluoranthene (B[b]F) by gavage for 90 and 180 d was assessed by CarcSeq.
Faske JB, Gong B, LeBlanc DP, Funk J, Zhou G, Kehm S, White PA, Robison T, Zeller A, Yauk CL, Marchetti F, Parsons BL.   +11 more
europepmc   +3 more sources

Scientific opinion on the renewal of the authorisation of Zesti Smoke Code 10 (SF‐002) as a smoke flavouring Primary Product

EFSA Journal, Volume 21, Issue 11, November 2023., 2023
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product Zesti Smoke Code 10 (SF‐002), for which a renewal application was submitted in accordance with Article 12(1) of Regulation (EC) No 2065/2003.
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Ullrika Sahlin, Maria Carfì, Carla Martino, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +29 more
wiley   +1 more source

Scientific opinion on the renewal of the authorisation of Smoke Concentrate 809045 (SF‐003) as a smoke flavouring Primary Product

EFSA Journal, Volume 21, Issue 11, November 2023., 2023
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product Smoke Concentrate 809045 (SF‐003), for which a renewal application was submitted in accordance with Article 12(1) of Regulation (EC) No 2065/2003.
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Ullrika Sahlin, Maria Carfì, Blanka Halamoda, Carla Martino, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +30 more
wiley   +1 more source