Results 131 to 140 of about 1,179,318 (342)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

An Empirical Evaluation of Manually Created Equivalent Mutants [PDF]

arXiv
Mutation testing consists of evaluating how effective test suites are at detecting artificially seeded defects in the source code, and guiding the improvement of the test suites. Although mutation testing tools are increasingly adopted in practice, equivalent mutants, i.e., mutants that differ only in syntax but not semantics, hamper this process ...
arxiv  

HOMOLOGOUS EYE COLOR MUTANTS IN THE HONEYBEE AND DROSOPHILA [PDF]

, 1955
M. M. Green
openalex   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

UTILIZATION OF PSEUDOVITAMIN B ₁₂ BY MUTANTS OF ESCHERICHIA COLI [PDF]

, 1952
Bernard D. Davis
openalex   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

THE PROPORTION OF TERRAMYCIN-RESISTANT MUTANTS IN B. MEGATHERIUM CULTURES [PDF]

, 1957
John H. Northrop
openalex   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Leveraging Propagated Infection to Crossfire Mutants [PDF]

arXiv
Mutation testing was proposed to identify weaknesses in test suites by repeatedly generating artificially faulty versions of the software (mutants) and determining if the test suite is sufficient to detect them (kill them). When the tests are insufficient, each surviving mutant provides an opportunity to improve the test suite. We conducted a study and
arxiv  

COMPARATIVE STUDY OFESCHERICHIA COLIPHAGE T1 AND A PLAQUE TYPE MUTANT [PDF]

, 1958
Ruth F. Hill
openalex   +1 more source