Results 131 to 140 of about 2,159,893 (336)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Impact of segmental chromosomal duplications on leaf size in the grandifolia‐D mutants of Arabidopsis thaliana [PDF]

, 2009
Gorou Horiguchi, Nathalie González, Gerrit T.S. Beemster, Dirk Inzé, Hirokazu Tsukaya   +4 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Retrograde Signaling and Photoprotection in a gun4 Mutant of Chlamydomonas reinhardtii [PDF]

, 2012
Cinzia Formighieri, Mauro Ceol, Giulia Bonente, Jean‐David Rochaix, Roberto Bassi   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Uncoupled Phosphorylation and Activation in Bacterial Chemotaxis - The 2.3 Å structure of an aspartate to lysine mutant at position 13 of CheY [PDF]

, 1997
An aspartate to lysine mutation at position 13 of the chemotaxis regulatory protein CheY causes a constitutive tumbly phenotype when expressed at high copy number in vivo even though the mutant protein is not phosphorylatable.
Bourret, Robert B., Jiang, Meiying, Sinsheimer, Melvin I., Volz, Karl   +3 more
core  

Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRα-Derived Entry Inhibitors [PDF]

, 2021
Kerstin Laib Sampaio, Carolin Lutz, Rebecca Engels, Dagmar Stöhr, Christian Sinzger   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

bk-5214S2L, an allelic variant of bk-5, as high-quality silage maize genetic resource

Frontiers in Genetics
IntroductionStem brittleness significantly affects both yield and quality of maize.MethodsUsing phenotypic identification and sequence analysis, we identified a new brittle stalk maize mutant.
Gang Li, Jiyuan Du, Xiaohu Li, Shilin Zhuge, Shuolin Ren, Min Wu, Haoran Ma, Xinrui Guo, Ziqiang Chen, Haiping Ding   +9 more
doaj   +1 more source

Mutants and SU(3)_q invariants [PDF]

, 1998
Details of quantum knot invariant calculations using a specific SU(3)_q-module are given which distinguish the Conway and Kinoshita-Teresaka pair of mutant knots. Features of Kuperberg's skein-theoretic techniques for SU(3)_q invariants in the context of
Morton, H. R., Ryder, H. J.
core   +1 more source