Results 161 to 170 of about 2,913,254 (384)

OHIO-1 β-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime [PDF]

, 2006
Robert A. Bonomo, Susan D. Rudin, David M. Shlaes   +2 more
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Got the Blues? A High-Throughput Screen for Cyanogenesis Mutants [PDF]

, 2010
Gregory Bertoni
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Curing of a Sporulation Mutant and Antibiotic Activity of Bacillus subtilis [PDF]

, 1968
Rüdiger Schmitt, Ernst Freese
openalex   +1 more source

Mutant meristems [PDF]

Current Biology, 1999
openaire   +2 more sources

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.

Cancer Discovery, 2018
F. Skoulidis, M. Goldberg, D. Greenawalt, M. Hellmann, M. Awad, J. Gainor, A. Schrock, R. Hartmaier, S. Trabucco, L. Gay, Siraj M. Ali, J. Elvin, G. Singal, J. Ross, D. Fabrizio, P. Szabo, Han Chang, A. Sasson, S. Srinivasan, S. Kirov, J. Szustakowski, P. Vitazka, R. Edwards, J. Bufill, N. Sharma, S. Ou, N. Peled, D. Spigel, H. Rizvi, E. J. Aguilar, B. Carter, J. Erasmus, D. Halpenny, A. Plodkowski, N. Long, M. Nishino, W. Denning, Ana Galán-Cobo, Haifa Hamdi, Taghreed Hirz, P. Tong, Jing Wang, J. Rodriguez-Canales, P. Villalobos, E. Parra, N. Kalhor, L. Sholl, J. Sauter, A. Jungbluth, M. Mino‐Kenudson, Roxana Azimi, Y. Elamin, Jianjun Zhang, G. Leonardi, F. Jiang, Kwok-kin Wong, J. Lee, V. Papadimitrakopoulou, I. Wistuba, V. Miller, G. Frampton, J. Wolchok, A. Shaw, P. Jänne, P. Stephens, C. Rudin, W. Geese, L. Albacker, J. Heymach   +68 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

bk-5214S2L, an allelic variant of bk-5, as high-quality silage maize genetic resource

Frontiers in Genetics
IntroductionStem brittleness significantly affects both yield and quality of maize.MethodsUsing phenotypic identification and sequence analysis, we identified a new brittle stalk maize mutant.
Gang Li, Jiyuan Du, Xiaohu Li, Shilin Zhuge, Shuolin Ren, Min Wu, Haoran Ma, Xinrui Guo, Ziqiang Chen, Haiping Ding   +9 more
doaj   +1 more source

Mutants and SU(3)_q invariants [PDF]

, 1998
Details of quantum knot invariant calculations using a specific SU(3)_q-module are given which distinguish the Conway and Kinoshita-Teresaka pair of mutant knots. Features of Kuperberg's skein-theoretic techniques for SU(3)_q invariants in the context of
Morton, H. R., Ryder, H. J.
core   +1 more source