Results 11 to 20 of about 1,964,495 (300)

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong, Gao, Limo, Huang, Bo, Huang, Cao, Shi, Xinglong   +4 more
core   +2 more sources

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia

Disease Models & Mechanisms, 2019
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani, Tiziana Orsini, Alessia Gambadoro, Miriam Pasquini, Sabrina Putti, Maurizio Cirilli, Olga Ermakova, Glauco P. Tocchini-Valentini   +7 more
doaj   +1 more source

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
A Ali, A Mitchell, A Plaine, A Roetzer, A Roetzer, A Walther, A Winkler, AA Duina, AE Piispanen, Alex Andrianopoulos, Alistair J. P. Brown, AP Gasch, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, BK Jakobsen, C Csank, C Giardina, C Queitsch, C San Jose, CA Munro, Carol Munro, CH de Dios, CJ Nobile, D Chen, DA Davis, DA Smith, DF Jarosz, DF Jarosz, DF Smith, DM Arana, DR Wysong, E Kussell, E Leberer, E Nikolaou, E Roman, EA Craig, EA Elion, ET Burt, F Estruch, F Lamoth, F Navarro-Garcia, F Navarro-Garcia, F Navarro-García, F Sherman, FA Guhad, G Degols, G Wiederrecht, G Wiederrecht, GJ Gallo, H Garreau, H Lavoie, HC Causton, I Tirosh, IV Ene, J Chen, J Zou, JL Brewster, JR Blankenship, K-H Chen, LA Walker, LA Walker, LE Cowen, Leah E. Cowen, Louise Walker, M Ramsdale, M Taipale, MD Leach, MD Leach, MD Leach, MD Leach, ME Feder, Michelle D. Leach, MM Bradford, N Shulga, P Gónzalez-Párraga, P Hawle, PD Cantero, PK Sorger, PK Sorger, R Alonso-Monge, R Alonso-Monge, R Diez-Orejas, RA Monge, RB Wilson, RS Hegde, RS Shapiro, S Bates, S Diezmann, S Kuge, S Nicholls, S Nicholls, S Nicholls, SD Singh, SH Millson, SK Prill, SL LaFayette, SL Rutherford, SM Noble, SM O'Rourke, SM Roe, Susan Budge, TT Wimalasena, VM Bruno, VM Bruno, WA Fonzi, WM Toone, X Zhang, Y Guo, Y Kamada   +110 more
core   +3 more sources

Isolation of segmented filamentous bacteria from complex gut microbiota

BioTechniques, 2015
Segmented filamentous bacteria (SFB) modulate the ontogeny of the immune system, and their presence can significantly affect mouse models of disease. Until recently, the inability to successfully culture SFB has made controlled studies on the mechanisms ...
Aaron C. Ericsson, Giedre Turner, Lisa Montoya, Annie Wolfe, Stacey Meeker, Charlie Hsu, Lillian Maggio-Price, Craig L. Franklin   +7 more
doaj   +1 more source

Beelden van de professional

Journal of Social Intervention, 2016
Ed de Jonge. Beelden van de Professional. Inspiratiebronnen voor professionalisering. Delft: Eburon, 2015, 409 p., €35,00.
Fuusje de Graaff
doaj   +1 more source

Genetic Dissection of the Drosophila Nervous System by means of Mosaics [PDF]

, 1970
Given a mutant having abnormal behavior, the anatomical domain responsible for the deficit may be identified by the use of genetic mosaicism. Individuals may be produced in which a portion of the body is mutant male while the rest is normal female.
Benzer, Seymour, Hotta, Yoshiki
core   +1 more source

Mutant Insulin Syndromes [PDF]

Hormone and Metabolic Research, 1988
Highly sensitive procedures for the characterization of molecular species of insulin in the circulation and for the isolation of the gene encoding human insulin have recently been developed. Nine subjects with abnormal forms of insulin or proinsulin have been reported.
A, Vinik, G, Bell
openaire   +2 more sources

Effect of Shipping on the Microbiome of Donor Mice Used to Reconstitute Germ-Free Recipients

Gut Microbes Reports
The gut microbiome (GM) influences multiple processes during host development and maintenance. To study these events, fecal microbiota transfer (FMT) to germ-free (GF) recipients is often performed.
Zachary L. McAdams, Jared Yates, Giedre Turner, Rebecca A. Dorfmeyer, Mary Wight-Carter, James Amos-Landgraf, Craig L. Franklin, Aaron C. Ericsson   +7 more
doaj   +1 more source

Evaluating Random Mutant Selection at Class-Level in Projects with Non-Adequate Test Suites

, 2016
Mutation testing is a standard technique to evaluate the quality of a test suite. Due to its computationally intensive nature, many approaches have been proposed to make this technique feasible in real case scenarios.
Demeyer, Serge, Murgia, Alessandro, Parsai, Ali   +2 more
core   +1 more source

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL. [PDF]

, 2017
Casitas B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is important for non-small-cell lung cancer (NSCLC). We investigated if MET is a target of CBL and if enhanced in CBL-altered NSCLC.
Batra, Surinder K, Husain, Aliya N, Mirzapoiazova, Tamara, Salgia, Ravi, Sharma, Sherven, Srivastava, Minu K, Tan, Yi-Hung Carol, Vokes, Everett E, Won, Brian M, Zhu, Li   +9 more
core   +1 more source