Results 11 to 20 of about 1,483,986 (159)

On the establishment of a mutant [PDF]

Journal of Mathematical Biology, 2020
AbstractHow long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011.https://doi.org/10.1080/17513758.2010.506041)
Jeremy Baker, Pavel Chigansky, Peter Jagers, Fima C. Klebaner   +3 more
openaire   +4 more sources

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation [PDF]

, 2016
Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear.
Schneider, RK, Losman, JA, Perales-Patón, J., Tothova, Z., Peskier, F., Mullally, A., Losman, J.A., Giannini, S, Al-Shahrour, F, Chen, E, Rosen, EA, Chen, E., Al-Shahrour, F., Giannini, S., Ko, A, Elf, S, Abdelfattah, N.S., Wolach, O., Morgan, E.A., Schneider, R.K., Florescu, N, Mullally, A, Elf, S., Florescu, N., Wolach, O, Morgan, EA, Ko, A., Peisker, F, Perales-Patón, J, Tothova, Z, Abdelfattah, NS, Rosen, E.A.   +31 more
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Studies on the morphology of the inner ear and semicircular canal endorgan projections of ha, a medaka behavior mutant [PDF]

, 2007
2007The morphology of the inner ear was investigated in the mutant strain ha of medaka (Oryzias latipes). The ha is a recessive mutant and ha homozygotes are viable but show abnormal circular swimming behavior.
Yamamoto, Naoyuki, Noro, Shin-ichi, Ishikawa, Yuji, Ito, Hironobu, Ijiri, Kenichi   +4 more
core   +1 more source

Innovative approaches to monitor mutant huntingtin and to facilitate its degradation in Huntington's disease models [PDF]

, 2011
Huntington’s disease (HD) is a dominant genetic neurodegenerative disease caused by a mutation in the exon 1 of the huntingtin gene. The clinical symptoms, such as motor disturbances (chorea), cognitive decline and psychiatric impairments are usually ...
Baldo, Barbara
core   +1 more source

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Hazel P Williams, Greensmith Linda, Francesca Achilli, Ruth Chia, Elizabeth M. C. Fisher, Hazel P. Williams, Fisher Elizabeth M. C., Achilli, F., Chia, R, Bryson, J.B., Bros-Facer, V., Greensmith, L., Bros-Facer, V, Banks, G.T., Bryson, JB, Banks, GT, Fisher, EMC, Bros-Facer Virginie, Linda Greensmith, Fisher, E.M.C., Banks Gareth T., Chia, R., Gareth T Banks, Williams, HP, Greensmith, L, Williams Hazel P., Elizabeth M C Fisher, J Barney Bryson, Gareth T. Banks, Virginie Bros-Facer, Achilli Francesca, Williams, H.P., Bryson J. Barney, Chia Ruth, J. Barney Bryson, Achilli, F   +35 more
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Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot [PDF]

, 2010
Gross similarities between the external appearance of the hind limbs of the peroneal muscle atrophy (pma) mouse mutant and congenital talipes equinovarus (CTEV), a human disorder historically referred to as 'clubfoot', suggested that this mutant could be
Liu, Guoqing, Miedzybrodzka, Zosia, Schmidt, Katy, Chudek, Sandy, Tickle, Cheryll, Duce, Suzanne, Cunningham, Craig; id_orcid, Madrigal, Londale, Barker, Simon, Tennant, Gordon   +9 more
core   +1 more source

Structure-Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]

, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan, Alfain Noerdin Alimny, Diah Amelia, Wiwin Retnowati, NIDN. 0009046803, Sri Puji Astuti Wahyuningsih, NIDN. 0021026604   +4 more
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Construction and characterization of a glycoprotein E deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil [PDF]

, 2002
This paper describes the construction and characterization of a Brazilian strain of bovine herpesvirus type 1.2a (BoHV-1.2a) with a deletion of the glycoprotein E (gE) gene. The deletion was introduced by co-transfection of a deletion fragment containing
Rijsewijk, F.A.M., Franco, A.C., Flores, E.F., Weiblen, R., Roehe, P.M.   +4 more
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Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2 [PDF]

, 2022
Spinocerebellar ataxia type 2 (SCA2) is a rare autosomal, dominantly inherited disease, in which the affected individuals have a disease onset around their third life decade. The molecular mechanisms underlying SCA2 are not yet completely understood, for
André Conceição, Afonso, Inês T., Inês T. Afonso, Clévio Nóbrega, Carlos A. Matos, Matos, Carlos A., Matos, Carlos A, Patrícia Lima, Conceição, André, Lima, Patrícia, Nóbrega, Clévio   +10 more
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The MutAnts Are Here [PDF]

Cell, 2017
The development of CRISPR/Cas9-mediated gene knockout in two ant species opens a new window into exploring how social insects use olfactory cues to organize their collective behavior.
Daniel A, Friedman, Deborah M, Gordon, Liqun, Luo   +2 more
openaire   +2 more sources