Results 11 to 20 of about 1,574,250 (305)

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation [PDF]

, 2016
Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear.
Schneider, RK, Losman, JA, Perales-Patón, J., Tothova, Z., Peskier, F., Mullally, A., Losman, J.A., Giannini, S, Al-Shahrour, F, Chen, E, Rosen, EA, Chen, E., Al-Shahrour, F., Giannini, S., Ko, A, Elf, S, Abdelfattah, N.S., Wolach, O., Morgan, E.A., Schneider, R.K., Florescu, N, Mullally, A, Elf, S., Florescu, N., Wolach, O, Morgan, EA, Ko, A., Peisker, F, Perales-Patón, J, Tothova, Z, Abdelfattah, NS, Rosen, E.A.   +31 more
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Innovative approaches to monitor mutant huntingtin and to facilitate its degradation in Huntington's disease models [PDF]

, 2011
Huntington’s disease (HD) is a dominant genetic neurodegenerative disease caused by a mutation in the exon 1 of the huntingtin gene. The clinical symptoms, such as motor disturbances (chorea), cognitive decline and psychiatric impairments are usually ...
Baldo, Barbara
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Construction and characterization of a glycoprotein E deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil [PDF]

, 2002
This paper describes the construction and characterization of a Brazilian strain of bovine herpesvirus type 1.2a (BoHV-1.2a) with a deletion of the glycoprotein E (gE) gene. The deletion was introduced by co-transfection of a deletion fragment containing
Rijsewijk, F.A.M., Franco, A.C., Flores, E.F., Weiblen, R., Roehe, P.M.   +4 more
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Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Hazel P Williams, Greensmith Linda, Francesca Achilli, Ruth Chia, Elizabeth M. C. Fisher, Hazel P. Williams, Fisher Elizabeth M. C., Achilli, F., Chia, R, Bryson, J.B., Bros-Facer, V., Greensmith, L., Bros-Facer, V, Banks, G.T., Bryson, JB, Banks, GT, Fisher, EMC, Bros-Facer Virginie, Linda Greensmith, Fisher, E.M.C., Banks Gareth T., Chia, R., Gareth T Banks, Williams, HP, Greensmith, L, Williams Hazel P., Elizabeth M C Fisher, J Barney Bryson, Gareth T. Banks, Virginie Bros-Facer, Achilli Francesca, Williams, H.P., Bryson J. Barney, Chia Ruth, J. Barney Bryson, Achilli, F   +35 more
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On the establishment of a mutant [PDF]

Journal of Mathematical Biology, 2020
AbstractHow long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011.https://doi.org/10.1080/17513758.2010.506041)
Jeremy Baker, Pavel Chigansky, Peter Jagers, Fima C. Klebaner   +3 more
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Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot [PDF]

, 2010
Gross similarities between the external appearance of the hind limbs of the peroneal muscle atrophy (pma) mouse mutant and congenital talipes equinovarus (CTEV), a human disorder historically referred to as 'clubfoot', suggested that this mutant could be
Liu, Guoqing, Miedzybrodzka, Zosia, Schmidt, Katy, Chudek, Sandy, Tickle, Cheryll, Duce, Suzanne, Cunningham, Craig; id_orcid, Madrigal, Londale, Barker, Simon, Tennant, Gordon   +9 more
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Comparative Analysis of Volatile Compounds of Gamma-Irradiated Mutants of Rose (Rosa hybrida)

Plants, 2020
Roses are one of the most important floricultural crops, and their essential oils have long been used for cosmetics and aromatherapy. We investigated the volatile compound compositions of 12 flower-color mutant variants and their original cultivars ...
Jaihyunk Ryu, Jae Il Lyu, Dong-Gun Kim, Jung-Min Kim, Yeong Deuk Jo, Si-Yong Kang, Jin-Baek Kim, Joon-Woo Ahn, Sang Hoon Kim   +8 more
doaj   +1 more source

Purified single-mutant and double-mutant chromatograms.

, 2023
(A–H) Sanger sequencing chromatograms of single- and double-mutant phage lysates. Single-mutant phages were generated by exposure to crRNAs with mismatches (MM crRNA) at different positions (position X) and purified as shown in Fig 7A.
Michael A. Schelling (15295682), Giang T. Nguyen (2830358), Dipali G. Sashital (5721161)   +2 more
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-Mutant Cancers [PDF]

, 2023
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabolite ...
Julie-Aurore Losman, Koivunen, Peppi, Yan, Hai, Samuel K. McBrayer, Kathryn Gunn, Hai Yan, Ligon, Keith L, Gunn, Kathryn, Kornblum, Harley I, John Z. Cao, Manna Ahmed, Harley I. Kornblum, Huang, Bofu, Ryan Looper, Levitt, Michael M, Losman, Julie-Aurore, Diplas, Bill H, Cihangir Duy, Matti Myllykoski, Bill H. Diplas, Duy, Cihangir, Ahmed, Manna, Cao, John Z, Rouaisnel, Betty, Keith L. Ligon, Doench, John G, John G. Doench, Myllykoski, Matti, Lucy A. Godley, Looper, Ryan, McBrayer, Samuel K, Godley, Lucy A, Betty Rouaisnel, Michael M. Levitt, Bofu Huang, Peppi Koivunen   +35 more
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Egy virulencia regulátor mutáns Salmonella enterica törzs mint kereszt-immunitást biztosító orális vakcina jelölt vizsgálata = Investigation of a virulence regulator mutant strain of Salmonella enterica as a candidate for live oral vaccine providing cross-immunity [PDF]

, 2008
Kutatásaink során egy Salmonella rfaH mutánst mint potenciális vakcina jelöltet vizsgáltunk több aspektusból. Mivel az RfaH fehérje egy transzkripciós regulátor, vizsgáltuk, hogy mely virulencia faktorokra kifejtett hatása okozza a vakcina törzs ...
Nagy, Gábor
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