Results 231 to 240 of about 2,828,087 (336)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dissecting the role of strigolactone perception in barley tolerance to cadmium or zinc stress based on the receptor mutant analysis. [PDF]

BMC Plant Biol
Buchcik W, Sitko K, Marzec M.
europepmc   +1 more source

Fluoroquinolone Resistance Mechanism of Clinical Isolates and Selected Mutants of Pasteurella multocida from Bovine Respiratory Disease in China

, 2014
Lingcong Kong, Duo Gao, Yunhang Gao, Shuming Liu, Hongxia Ma   +4 more
openalex   +2 more sources

A group B Streptococcus indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen

, 2023
Venkata Hemanjani Bhavana, Gideon H. Hillebrand, Kathyayini P. Gopalakrishna, Rebekah A. Rapp, Adam J. Ratner, Hervé Tettelin, Thomas A. Hooven   +6 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A novel MRI diffusion metric 'slow diffusion coefficient' (SDC) for diagnosing isocitrate dehydrogenase (IDH) genotype in diffuse gliomas: initial promising results. [PDF]

BMC Med Imaging
Zheng WY, Shi YT, He YY, Lin RL, Xiao BH, Jiang RF, Wáng YXJ.   +6 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Rebalancing the seed proteome following deletion of vicilin-related genes in pea (Pisum sativum L.). [PDF]

J Exp Bot
Rayner T, Saalbach G, Vickers M, Paajanen P, Martins C, Wouters RHM, Chinoy C, Mulholland F, Bal M, Isaac P, Novak P, Macas J, Ellis N, Steuernagel B, Domoney C.   +14 more
europepmc   +1 more source

The contribution of mutant amino acids to alloantigenicity. [PDF]

, 1989
J Bill, Franca Ronchese, Ronald N. Germain, Ed Palmer   +3 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source