Results 231 to 240 of about 2,114,568 (336)

Metformin modulates mitochondrial metabolism and epigenetic dysregulation in DNMT3A-mutated clones. [PDF]

Mol Biomed
Hu X, Wang B, Zhang L.
europepmc   +1 more source

Preliminary Notes on the Development of the Wings in Normal and Mutant Strains of Drosophila [PDF]

, 1939
C. H. Waddington
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Distinct molecular subtypes of KRAS^G12C-mutant lung adenocarcinoma: Insights into clinical outcomes, tumour microenvironments and therapeutic strategies. [PDF]

Clin Transl Med
Yang H, Zhu A, Niu Y, Ma W, Xu K, Jia Y, Xu W, Zhao B, Zhang E, Jia J, Liang S, Dorn P, Liu G, Peng RW, Yao F.   +14 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Effects of a novel loss-of-function waxy endosperm allele on sorghum seed development and grain quality. [PDF]

G3 (Bethesda)
Dhiman P, Soumen S, Nigam D, Bean SR, Wu X, Patil GB, Xin Z, Jiao Y.   +7 more
europepmc   +1 more source

Nutritional Studies of Cysteineless Mutants of Salmonella typhimurium

, 1958
Royston C. Clowes
openalex   +1 more source

CYTOLOGIC STUDIES ON THE ABNORMAL DEVELOPMENT OF THE EGGS OF THE CLARET MUTANT TYPE OF DROSOPHILA SIMULANS [PDF]

, 1936
Helena Wald
openalex   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Phosphate sensing by PhoPR regulates the cytotoxicity of <i>Staphylococcus aureus</i>. [PDF]

Microbiology (Reading)
Palk N, Brignoli T, Boura M, Massey RC.
europepmc   +1 more source