Results 241 to 250 of about 2,913,254 (384)

Salt Tolerance and Screening for Genetic Changes in Rice Mutants after Gamma Irradiation Using RAPD and Microsatellite (RAMP) Markers [PDF]

, 2009
Thuc Oanh Hoang, L.F. De Filippis, Xiao-hua Le   +2 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

GENETIC CONTROL OF PHOSPHORUS ASSIMILATION IN NEUROSPORA CRASSA: DOSE-DEPENDENT DOMINANCE AND RECESSIVENESS IN CONSTITUTIVE MUTANTS [PDF]

, 1979
Robert L. Metzenberg, William Chia
openalex   +1 more source

Quick creation and mapping of EMS-induced maize kernel mutants identifies classical gene ZmBT1 and novel gene ZmTOP6A. [PDF]

Plant Genome
Dong H, Chen H, Jiang Y, Zhang J, Wang C, Sun Z, Su S, Li S, Liu H, Shan X, Yuan Y.   +10 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance [PDF]

, 1992
I Weichselbraun, Johannes Berger, Marika Dobrovnik, Hal P. Bogerd, Ralph Grassmann, Warner C. Greene, Joachim Hauber, Ernst Böhnlein   +7 more
openalex   +1 more source

Nematode-trapping fungus Arthrobotrys oligospora is hungry for iron-chelating agent COQ7 of nematodes. [PDF]

Nat Prod Bioprospect
Wu Q, Zhou J, Wang D, Xue S, Li L, Wu L, Yan J, Niu X.   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models. [PDF]

Proc Natl Acad Sci U S A
Hassanzadeh K, Liu J, Zhang J, Tabari MA, Maddila S, Maral Mouradian M.   +5 more
europepmc   +1 more source

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Science, 2015
Jihye Yun, Edouard Mullarky, Changyuan Lu, Kaitlyn N. Bosch, A. Kavalier, Keith D. Rivera, Jatin Roper, I. I. C. Chio, Eugenia G. Giannopoulou, C. Rago, A. Muley, J. Asara, J. Paik, O. Elemento, Zhengming Chen, D. Pappin, L. Dow, N. Papadopoulos, S. Gross, L. Cantley   +19 more
semanticscholar   +1 more source