Results 251 to 260 of about 2,828,087 (336)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Phenotypic Complementation of High CO₂-Requiring Mutants of the Cyanobacterium Synechococcus sp. Strain PCC 7942 by Inosine 5′-Monophosphate [PDF]

, 1992
Rakefet Schwarz, J. Lieman-Hurwitz, Miriam Hassidim, Aaron Kaplan   +3 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries. [PDF]

NPJ Breast Cancer
Devakrishnan AK, Madasu C, Wang Y, Modukuri R, Bohren KM, MacKenzie KR, Young DW, Fuqua SAW, Matzuk MM, Palaniappan M.   +9 more
europepmc   +1 more source

Supplementary Figure S5 from Targeting ATP7A-Dependent Copper Metabolic Homeostasis Induces Cuproptosis and Suppresses the Progression of Mutant KRAS-Driven Lung Cancer

Jian Zhao, Weijie Zhang, Yuanyuan Zeng, Di Lu, Chenkang Ma, Mengzhu Zhang, Xin Cai, Zhifan Huang, Hongli Yang, Jianjun Li, Jianjie Zhu, Jian‐An Huang, Zeyi Liu   +12 more
openalex   +1 more source

A recombinant peptide model of the first nucleotide‐binding fold of the cystic fibrosis transmembrane conductance regulator: Comparison of wild‐type and ΔF508 mutant forms [PDF]

, 1996
Iwona Yike, Jin Ye, Yan Zhang, Parthasarathy Manavalan, Thomas Gerken, Dorr G. Dearborn   +5 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Methanol response of V171S lipase from Geobacillus sp. 42 explored via experimental and in silico approaches. [PDF]

AMB Express
Johan UUM, Ishak SNH, Latip W, Rahman RNZRA, Salleh AB, Leow ATC, Ali MSM.   +6 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Characterization of a wheat mutant line 1813WH presenting increased seed dormancy and longevity, and reduced pre-harvest sprouting. [PDF]

BMC Plant Biol
Li X, Li X, Zhu S, Han B, Xing Y, Li G, Yang Y.   +6 more
europepmc   +1 more source