Results 1 to 10 of about 198,463 (306)

Mutant p53 induces SH3BGRL expression to promote cell engulfment [PDF]

Cell Death Discovery
Previously, we identified that mutant p53 expression in cancer cells promotes engulfment of neighbouring cancer cells to form cell-in-cell (CIC) structures.
Lobsang Dolma, Mary I. Patterson, Antonia Banyard, Callum Hall, Steven Bell, Wolfgang Breitwieser, Sudhakar Sahoo, John Weightman, Maria Pazos Gil, Garry Ashton, Caron Behan, Nicola Fullard, Lewis D. Williams, Patricia AJ. Muller   +13 more
doaj   +2 more sources

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers [PDF]

iScience, 2020
Summary: Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.
Murilo M. Pedrote, Michelle F. Motta, Giulia D.S. Ferretti, Douglas R. Norberto, Tania C.L.S. Spohr, Flavia R.S. Lima, Enrico Gratton, Jerson L. Silva, Guilherme A.P. de Oliveira   +8 more
doaj   +4 more sources

Mutant p53 and TP53 mutations in esophageal squamous cell carcinoma: consistency and diagnostic significance [PDF]

Frontiers in Genetics
Background and objectiveTP53 mutation is an initiating event in tumorigenesis in many cancers. Mutant p53 expression is an important manifestation of TP53 mutations, however, this association has not yet been confirmed in esophageal squamous cell ...
Xueyu Zhuang, Na Lin, Yanjuan Xu
doaj   +2 more sources

Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers [PDF]

Biomolecules
Mutations in the p53 gene are frequently observed in various cancers, prompting the initiation of efforts to restore p53 function as a therapeutic approach several decades ago.
Na Zhang, Zhiyuan Jing, Jie Song, Qiyue Liang, Yuxue Xu, Zhaowei Xu, Longping Wen, Pengfei Wei   +7 more
doaj   +2 more sources

Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type [PDF]

EMBO Reports
To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically matched mouse strains. Response to radiation was used as
Ramy Rahmé, Lois Resnick-Silverman, Vincent Anguiano, Moray J Campbell, Pierre Fenaux, James J Manfredi   +5 more
doaj   +2 more sources

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]

, 2012
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Durkovic, Marina, Edlinger, Marlene, Flisikowska, Tatiana, Flisikowski, Krzysztof, Kessler, Barbara, Kind, Alexander, Kurome, Mayuko, Leuchs, Simon, Merkl, Claudia, Rezaei, Nousin, Saalfrank, Anja, Schnieke, Angelika, Wolf, Eckhard, Zakhartchenko, Valeri   +13 more
core   +10 more sources

Targeting mutant p53 stabilization for cancer therapy

Frontiers in Pharmacology, 2023
Over 50% cancer bears TP53 mutation, the highly stabilized mutant p53 protein drives the tumorigenesis and progression. Mutation of p53 not only cause loss-of-function and dominant-negative effects (DNE), but also results in the abnormal stability by the
Jiajian Wang, Wenjun Liu, Lanqing Zhang, Jihong Zhang, Jihong Zhang   +4 more
doaj   +1 more source

Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: p53 mutations are highly frequent in various human cancers and are reported to contribute to tumor malignance and chemoresistance. In this study, we explored the mechanism by which mutant p53 promotes carcinogenesis and chemoresistance and ...
Xiaolei Gao, Xiaolei Gao, Xiaolei Gao, Xiaolei Gao, Xuan Zheng, Xuan Zheng, Yixin Zhang, Yixin Zhang, Liying Dong, Liying Dong, Liangjie Sun, Liangjie Sun, Na Zhao, Na Zhao, Chong Ding, Zeyun Ma, Yixiang Wang, Yixiang Wang   +17 more
doaj   +1 more source

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

Genes and Diseases, 2022
The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive.
Shanshan Wang, Qian Hao, Jiajia Li, Yajie Chen, Hua Lu, Xiaohua Wu, Xiang Zhou   +6 more
doaj   +1 more source

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

Nature Communications, 2021
Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial ...
Tamara Isermann, Özge Çiçek Şener, Adrian Stender, Luisa Klemke, Nadine Winkler, Albrecht Neesse, Jinyu Li, Florian Wegwitz, Ute M. Moll, Ramona Schulz-Heddergott   +9 more
doaj   +1 more source