Results 261 to 270 of about 198,463 (306)

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source

GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function. [PDF]

Mol Cancer Res
Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D.   +16 more
europepmc   +1 more source

Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools. [PDF]

Sci Rep
Spiegelberg D, Hwang LA, Pua KH, Kumar SC, Koh XY, Koh XH, Selvaraju RK, Sabapathy K, Nestor M, Lane D.   +9 more
europepmc   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Anticancer therapeutic strategies for targeting mutant p53-Y220C. [PDF]

J Biomed Res
Chasov V, Davletshin D, Gilyazova E, Mirgayazova R, Kudriaeva A, Khadiullina R, Yuan Y, Bulatov E.   +7 more
europepmc   +1 more source

Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution. [PDF]

ACS Pharmacol Transl Sci
Klett T, Stahlecker J, Jaag S, Masberg B, Knappe C, Lämmerhofer M, Coles M, Stehle T, Boeckler FM.   +8 more
europepmc   +1 more source

Correction to: Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. [PDF]

Cell Death Differ
Hanel W, Marchenko N, Xu S, Yu SX, Weng W, Moll U.   +5 more
europepmc   +1 more source

Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway. [PDF]

Cancer Res Commun
Nakayama M, Saito H, Murakami K, Oshima H, Oshima M.   +4 more
europepmc   +1 more source

Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells. [PDF]

Cell Death Discov
Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M.   +4 more
europepmc   +1 more source

A Large Pigmented Lesion on the Abdomen of a Woman

JEADV Clinical Practice, EarlyView.
Ángel Fernández‐Camporro, Julián José Ahijado‐González, Eva Miranda‐Martínez   +2 more
wiley   +1 more source