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Cancer Discovery, 2023
Summary: p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p.
David P. Lane, Chandra S. Verma
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Summary: p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p.
David P. Lane, Chandra S. Verma
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Science Signaling, 2021
Arsenic trioxide may be effective against tumors with structural p53 mutations.
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Arsenic trioxide may be effective against tumors with structural p53 mutations.
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ATO stabilizes structural p53 mutants
Nature Reviews Cancer, 2021Chen et al. find that arsenic trioxide (ATO), an FDA-approved agent for acute promyelocytic leukaemia, can rescue common p53 structural mutants and restore p53 function.
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Trends in Cell Biology, 2010
Missense mutations in the p53 gene are commonly selected for in developing human cancer cells. These diverse mutations in p53 can inactivate its normal sequence-specific DNA-binding and transactivation function, but these mutations can also stabilize a mutant form of p53 with pro-oncogenic potential. Recent multi-disciplinary advances have demonstrated
Magda M, Maslon, Ted R, Hupp
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Missense mutations in the p53 gene are commonly selected for in developing human cancer cells. These diverse mutations in p53 can inactivate its normal sequence-specific DNA-binding and transactivation function, but these mutations can also stabilize a mutant form of p53 with pro-oncogenic potential. Recent multi-disciplinary advances have demonstrated
Magda M, Maslon, Ted R, Hupp
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Science Signaling, 2021
Mutant p53 takes the STING out of antitumor immunity.
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Mutant p53 takes the STING out of antitumor immunity.
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Mutant p53 expression in prostate carcinoma
The Prostate, 1993AbstractThe expression of the mutant p53 tumor suppressor gene was evaluated in 33 human prostate carcinomas. Using an immunohistochemical method with monoclonal antibodies PAb 1801 and PAb 240, 26 (79%) tumors demonstrated positive immunostaining for mutant p53.
P J, Van Veldhuizen +4 more
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Small molecules that reactivate mutant p53
European Journal of Cancer, 2003Around half of all human tumours carry mutant p53. This allows escape from p53-induced cell cycle arrest and apoptosis. Many tumours express mutant p53 proteins at elevated levels. Restoration of wild-type p53 function should trigger massive apoptosis in tumour cells and thus eradicate tumours. Various types of small molecules have been identified that
V J N, Bykov, G, Selivanova, K G, Wiman
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Temperature-Sensitive Mutants of p53 Homologs
Biochemical and Biophysical Research Communications, 2000Two homologs of the p53 tumor suppressor, p63 and p73 have recently been discovered. These proteins have activities similar to p53 in cell culture but have distinct developmental functions in vivo. We found that temperature-sensitive mutants of certain p63 and p73 isoforms can be created by single amino acid substitutions of an alanine residue ...
R, Pochampally +6 more
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