Results 51 to 60 of about 198,463 (306)

The SLC25A1-p53 mutant crosstalk

Aging, 2015
The presence of p53 mutations in human cancers, which occurs with a frequency higher than 50%, is a negative prognostic factor predictive of relapse and of resistance to chemo- and radio-therapy, thus rendering these types of tumors a still unsolved therapeutic challenge.
Chris, Albanese, Maria Laura, Avantaggiati   +1 more
openaire   +2 more sources

SNPing away at mutant p53 activities [PDF]

Genes & Development, 2018
A delicate balance in the levels of proteins that regulate the p53 tumor suppressor pathway exists such that subtle changes alter p53 tumor suppressor activity and cancer risk. Many single-nucleotide polymorphisms (SNPs) in the p53 pathway alter p53 transcriptional activity and are associated with cancer risk.
Ortiz, Guadalupe J., Lozano, Guillermina
openaire   +2 more sources

p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition

Journal of Experimental & Clinical Cancer Research, 2019
Background We reported previously that phenethyl isothiocyanate (PEITC), a dietary compound, can reactivate p53R175H mutant in vitro and in SK-BR-3 (p53R175H) breast xenograft model resulting in tumor inhibition. Because of the diversity of human cancers
Monika Aggarwal, Rahul Saxena, Nasir Asif, Elizabeth Sinclair, Judy Tan, Idalia Cruz, Deborah Berry, Bhaskar Kallakury, Quynhchi Pham, Thomas T. Y. Wang, Fung-Lung Chung   +10 more
doaj   +1 more source

Mutant p53 as a Regulator and Target of Autophagy

Frontiers in Oncology, 2021
One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene.
Yong Shi, Erik Norberg, Helin Vakifahmetoglu-Norberg   +2 more
doaj   +1 more source

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits [PDF]

, 2018
Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A- and B-type lamins.
Ana, Cumano, Bartolazzi, Armando, Bucciarelli, Elisabetta, Burla, Romina, Carcuro, Mariateresa, DEL GIUDICE, Simona, Gatti, Maurizio, Giulia, Piaggio, Ilaria, Virdia, Isabella, Manni, LA TORRE, Mattia, Merigliano, Chiara, Mottini, Carla, RAMPIONI VINCIGUERRA, GIAN LUCA, Riminucci, Mara, Saggio, Isabella, Silvia, Soddu, Verni', Fiammetta, Zanetti, Giorgia   +18 more
core   +1 more source

Mutant p53 in colon cancer

Journal of Molecular Cell Biology, 2018
The accumulation of genetic alterations in driver genes is responsible for the development and malignant progression of colorectal cancer. Comprehensive genome analyses have revealed the driver genes, including APC, KRAS, TGFBR2, and TP53, whose mutations are frequently found in human colorectal cancers. Among them, the p53 mutation is found in ~60% of
Mizuho Nakayama, Masanobu Oshima
openaire   +2 more sources

Mutant p53: one name, many proteins [PDF]

Genes & Development, 2012
There is now strong evidence that mutation not only abrogates p53 tumor-suppressive functions, but in some instances can also endow mutant proteins with novel activities. Such neomorphic p53 proteins are capable of dramatically altering tumor cell behavior, primarily through their interactions with other cellular proteins and regulation of cancer cell ...
William A, Freed-Pastor, Carol, Prives
openaire   +2 more sources

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

Nature Communications, 2021
The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of ...
Catherine A. Vaughan, Shilpa Singh, Mark A. Subler, Jolene J. Windle, Kazushi Inoue, Elizabeth A. Fry, Raghavendra Pillappa, Steven R. Grossman, Brad Windle, W. Andrew Yeudall, Swati Palit Deb, Sumitra Deb   +11 more
doaj   +1 more source

Chaperone-mediated autophagy degrades mutant p53 [PDF]

Genes & Development, 2013
Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53 proteins are known to actively contribute to tumor development and metastasis. Thus, promoting the removal of mutant p53 proteins in cancer cells may have therapeutic significance. Here we investigated
Vakifahmetoglu-Norberg, Helin, Kim, Minsu, Xia, Hong-guang, Iwanicki, Marcin P., Ofengeim, Dimitry, Coloff, Jonathan L., Pan, Lifeng, Ince, Tan A., Kroemer, Guido, Brugge, Joan S., Yuan, Junying   +10 more
openaire   +3 more sources

Mutant p53: an oncogenic transcription factor [PDF]

Oncogene, 2007
Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor suppressor activity, but gain new ...
S, Strano, S, Dell'Orso, S, Di Agostino, G, Fontemaggi, A, Sacchi, G, Blandino   +5 more
openaire   +2 more sources