Results 71 to 80 of about 198,463 (306)

Clinical Significance of Mutant P53 Protein Expression in Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2015
Background and objective P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of
Chun’an BIAN, Zhongyou LI, Youtao XU, Jie WANG, Lin XU, Hongbing SHEN   +5 more
doaj   +1 more source

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

Journal of Experimental & Clinical Cancer Research, 2018
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The TP53 is the most frequently inactivated gene in human cancers.
Giovanni Blandino, Silvia Di Agostino
doaj   +1 more source

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice [PDF]

, 2015
Huntingtons disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing ...
Bates, GP, Benjamin, AC, Carnemolla, A, Chini, EN, Jolinon, N, Smith, DL, Tulino, R   +6 more
core   +1 more source

Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function [PDF]

Molecular & Cellular Oncology, 2015
Many tumor-associated mutant p53 proteins gain new activities to promote tumorigenesis, which is termed as gain of function of mutant p53 (GOF). Currently, the mechanisms of mutant p53 GOF remain elusive. We recently identified the AAA+ ATPase pontin as a critical regulator of mutant p53 GOF, thus providing a novel mechanism for mutant p53 GOF.
Yuhan, Zhao, Xuetian, Yue, Wenwei, Hu
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Role of CaMK-II in the Development of Leukemia/Lymphoma in Danio Rerio [PDF]

, 2017
Acute lymphocytic leukemia (ALL) is a blood disorder characterized by aberrant proliferation of immature lymphocytes. ALL is the most common cancer in children and can result from external influences, such as radiation, or internal influences, such as ...
Mohammadi, Daniel
core   +1 more source

FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis [PDF]

, 2017
The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown.
Alfano, Vincenzo, Bozzoni, Irene, Colantoni, Alessio, DE SANTIS, Riccardo, DE TURRIS, Valeria, Peruzzi, Giovanna, Rosa, Alessandro, Santini, Laura   +7 more
core   +2 more sources

Targeting mutant p53 for cancer therapy

Aging, 2016
The p53 tumor suppressor protein serves as a major barrier against cancer; consequently, mutations in the TP53 gene, encoding p53, are the most frequent single genetic alteration in human cancer, occurring in about half of all individual cancer cases [1].
Oren, Moshe, Tal, Perry, Rotter, Varda
openaire   +2 more sources

Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53 [PDF]

Cell Death & Differentiation, 2015
Tumor-suppressor p53 is frequently mutated in human cancers. Many tumor-associated mutant p53 (mutp53) proteins gain new functions in promoting tumorigenesis, defined as gain-of-function (GOF). The mechanisms for mutp53 GOF are not well understood. Here, we report Pontin, a highly conserved AAA+ ATPase important for various cellular functions, as a new
Y, Zhao, C, Zhang, X, Yue, X, Li, J, Liu, H, Yu, V A, Belyi, Q, Yang, Z, Feng, W, Hu   +9 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source