Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans [PDF]
, 2014 Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed ...
Alland, David +9 more
core +13 more sources
Self-adaptation of mutation distribution in evolution strategies for dynamic optimization problems [PDF]
, 2011 Copyright @ IOS Press. All Rights Reserved.Evolution strategies with q-Gaussian mutation, which allows the self-adaptation of the mutation distribution shape, is proposed for dynamic optimization problems in this paper.
Tinós, R, Yang, S
core +4 more sources
The genetic equidistance result of molecular evolution is independent of mutation rates [PDF]
, 2008 The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity.
Shi Huang
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Use of the q-Gaussian mutation in evolutionary algorithms [PDF]
, 2010 Copyright @ Springer-Verlag 2010.This paper proposes the use of the q-Gaussian mutation with self-adaptation of the shape of the mutation distribution in evolutionary algorithms.
A Obuchowicz +28 more
core +3 more sources
Generalized Hybrid Evolutionary Algorithm Framework with a Mutation Operator Requiring no Adaptation [PDF]
, 2017 This paper presents a generalized hybrid evolutionary optimization structure that not only combines both nondeterministic and deterministic algorithms on their individual merits and distinct advantages, but also offers behaviors of the three originating ...
Chan, Lipton +4 more
core +1 more source
An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci [PDF]
, 2010 A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event
A. Eyre-Walker +60 more
core +2 more sources
Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2015 Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
core +2 more sources
Mutation testing from probabilistic finite state machines [PDF]
, 2007 Mutation testing traditionally involves mutating a program in order to produce a set of mutants and using these mutants in order to either estimate the effectiveness of a test suite or to drive test generation.
Hierons, RM, Merayo, MG
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Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source
BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. [PDF]
, 2014 Erdheim-Chester disease (ECD) is a rare histiocytosis with a high prevalence of BRAF V600E mutation (>50% of patients). Patients with BRAF-mutant ECD can respond to BRAF inhibitors.
Cabrilo, Goran +12 more
core +3 more sources