Results 271 to 280 of about 176,674 (312)

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Computational Analysis of SPI1 Missense Mutations and ADMET-Guided Molecular Docking of Cinnamic Acid Targeting the PU.1 ETS Domain: Implications for Hematopoietic Dysregulation and Leukemogenesis. [PDF]

Int J Mol Sci
Jaddah MM, Khalaf SN, Ahmed MM, Alshanqiti AA.   +3 more
europepmc   +1 more source

Structure of the Arabidopsis receptor kinase SRF6 ectodomain determined from crystals obtained using the LRR crystallization screen

Acta Crystallographica Section D, EarlyView.
A crystallization screen that has enabled the structural analysis of various extracellular domains of plant membrane receptor kinases is described together with the structure of the LRR domain of the receptor SRF6.Plant‐specific membrane receptor kinases with structurally diverse extracellular domains regulate key processes in plant growth, development,
Alberto Caregnato, Ulrich Hohmann, Michael Hothorn   +2 more
wiley   +1 more source

Molecular Mechanisms of CLCN5 Missense Mutations in Dent Disease Type 1: A Comprehensive Computational Analysis and Clinical Correlations in a Chinese Cohort. [PDF]

J Cell Mol Med
Wu C, Zhang Y, Chen Z, Fu H, Du Z, Chen L, Wang G, Mao J, Hu L.   +8 more
europepmc   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases. [PDF]

MedComm (2020)
Cao S, Wang T, Lv C, Ma S, Yu G, Xia Q, Liu T, Yu Y, Sun L, Pei X, Zhao Q, Wang Z, Wang C, Liu Y, Chen S, Wang J, Zhou G, Liu H, Sun Y, Zhang F.   +19 more
europepmc   +1 more source

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity. [PDF]

Nat Commun
Cooper GW, Lee BP, Kim WJ, Su Y, Chen VZ, Salas E, Yang X, Lintner RE, Piccioni F, Giacomelli AO, Howard TP, Bagchi P, Conneely KN, Root DE, Liang B, Gumbart JC, Hahn WC, Gorkin DU, Biegel JA, Chi SN, Hong AL.   +20 more
europepmc   +1 more source

FLVCR1-related diseases: from clinical heterogeneity to mechanistic insights. [PDF]

Brain Commun
Zanin Venturini DI, Chiabrando D.
europepmc   +1 more source